Coag Flashcards
1
Q
Intrinsic
A
Starts from 12
Intrinsic: longer
12, 11, 9, 8, 10
then common 5,2,1 (multiply to get 10)
SEC(subendothelial collagen)
PTT
HEP
2
Q
Extrinsic
A
Starts from 7
Extrinsic: short
7, 10
then common 5,2,1 (multiply to get 10)
TT (tissue thromboplatinc)
PT
Coumadin
3
Q
Plasmin
A
Activated by fibrinolytic system from kallikrein
Converts C3 to C3a
Degrades fibrin mesh
4
Q
How does 2a regulate the cascade
A
2A converts inactive 5 to 5a to positively regulate
2A converts inactive 8 to 8a to positively regulate
5
Q
What step needs Ca2+ and phospholipid
A
11A 9A + 8A 10A 7 to 7A 7A to convert 10
6
Q
What activates prekallinkrein to kallikrein
A
12A
7
Q
What does kallikrein do
A
Converts HMWK to bradykinin
Converts plasminogen to plasmin
8
Q
What activates 12?
A
HMWK
SEC
HMWK converts 12, to convert prekallikrein,
then kallikrein converts HMWK to bradykinin
