Anatomy Flashcards
RBC
120 days
Energy: glucose (90% glycolysis, 10% HMP shunt)
Cl-/HCO3- antiporter, to sequester HCO3_ and transport CO2 from the periphery to the lung
Anisocytosis vs. poikilocytosis
Anisocytosis: varying size
Poikilocytosis: varying shape
Platelet
8-10 days
Dense granule: ADP and Ca2+
alpha granule: vWF, fibrinogen
About 1/3 stored in the spleen.
vWF receptor vs. fibrinogen receptor
vWF: Gp1B
Fibrinogen: GpIIb/IIIa
Blood cell diff
Neutrophil 50 Lymphocyte 20 Monocyte 5 Eos 2 Baso 1
Neutrophils like making everything better.
Neutrophils
Small, numerous granules: alk phos, collagenase, lysozyme, lactoferrin
Larger, fewer granules (lysosome): acid phosphatase, peroxidase, beta glucuronidase.
Neutrophil:
changes
Hypersegmented 5 or more = vit B12
Increased band cells: increased myeloid proliferation (bacterial infections, CML)
Monocytes
Kidney shaped nucleus
Frost glass cytoplasm
differentiate into macrophages.
Macrophages
Long life tin tissue
CD14 marker (think of lucky x2)
Eosinophils
Helminthic infection
Bilobate nucleus
Highly phagocytic for Ag-Ab complex
Produces histaminase and arylsulfatase to help limit reaction following mast cell degranulation
Eosinophils seen in
NAACP
Neoplastic Asthma Allergic processes Collagen vascular dz Parasites (invasive)
Basophils
Allergic reaction
Basophilic granule: heparin, histamine, LTD4
Stains with BASIC stains.
Mast cells
Allergic reaction in local tissues
Resemble basophils structurally and functionally
but are NOT the same cell type
Binds to Fc portion of IgE to membrane, causing degranulation of histamine, heparin eosinophil chemotactic factors.
Type I HS
Cromolyn sodium prevents mast cell degranulation
Plasma cells
Off center nucleus
Clock face chromatin distribution
