CNSDrugs

Question 1

Brand Version and primary indication of Labetalol

Answer 1

Trandate

HTN

Question 2

MOA of labetalol

Answer 2

alpha and beta adrenergic receptor blocker

Question 3

MOA and primary indication of phenoxybenzamine

Answer 3

a1 postsynaptic receptor & a2 presynaptic receptor blocker

HTN associated w/ pheochromocytoma

Question 4

Important side effects of Labetalol

Answer 4

Orthostatic hypotension, bronchospasms, HF

Question 5

MOA and primary indication of Phentolamine

Answer 5

a1 and a2 adrenergic receptor blocker

HTN associated w/ pheochromocytoma

Question 6

MOA and primary indication of Prazosin, Terazosin and Doxazosin

Answer 6

Selectively block a1 adrenergic receptors

HTN

Question 7

Key adverse effects of Prazosin and related drugs

Answer 7

Postural hypotension and reflex tachycardia

Also Na and water retention

Question 8

Key adverse effects of Phentolamine and Phenoxybenzamine

Answer 8

Postural hypotension, N/V, miosis, tachycardia, increased blood volume (after long-term use)

Question 9

MOA and primary indication of Yohimbine

Answer 9

a2 adrenergic receptor blocker

HTN

Question 10

Brand name of Propranolol HCl

Answer 10

Inderal

Question 11

MOA of Propranolol

Answer 11

Blocks B1 adrenergic receptors on the heart, thereby directly depressing both SA nodal automaticity and AV nodal conduction

Question 12

Adverse effects of Propranolol

Answer 12

Hypoglycemia, cold extremities, bradycardia, bronchospasms, sodium and water retention

Question 13

MOA of Nadolol and Timolol

Answer 13

Non-selective B adrenergic receptor blockers

Question 14

Primary indication of Nadolol

Answer 14

HTN

Question 15

Primary indications of Timolol

Answer 15

HTN and open-angle glaucoma (topical)

Question 16

Brand name of Metoprolol succinate

Answer 16

Toprol-XL

Question 17

Brand name of metoprolol tartrate

Answer 17

Lopressor

Question 18

Primary indication of Metoprolol succinate

Answer 18

HTN, MI, HF

Question 19

Primary indication of Metoprolol tartrate

Answer 19

HTN, MI

Question 20

MOA of Betaxolol, Atenolol, and Metoprolol

Answer 20

Selective B1 adrenergic receptor blocker

Question 21

MOA and primary indication of Pindolol and Acebutolol

Answer 21

B1 & B2 receptor partial agonist

HTN, typically in pt’s w/modest bradycardia or diabetes