CNS Trauma Intro Flashcards
Most important thing oligodendrocytes do
produce myelin
Most important thing astrocytes do
react to injury
Most important thing microglia do
phagocytose intruders
Most important thing ependymal cells do
Line ventricles
How do astrocytes differ from oligodendrocytes on an H&E stain?
Astrocytes are bigger and generally have looser chromatin. Oligodendrocytes have a staining free halo around them
What do neurons look like that have undergone acute injury?
turn red in stain
Chronic injury results in what kind of damage to a neuron?
degeneration
What is axonal reaction?
when axons are severed off of neurons and the cell body swells
What are axonal spheroids?
When a part of the axon stains darker, indicating damage to the axon.
Cowdry bodies are found in neurons that are…
Infected with herpes
Negri bodies are found in cells that are…
infected with rabies
Things astrocytes do to respond to injury
Gliosis (astrocytic proliferation) •Gemistocytic astrocytes •Cytoplasmic swelling •Inclusion bodies •Rosenthal fibers •Corpora amylacea
Rosenthal fibers are…
thick, elongated, worm-like or “corkscrew” eosinophilic bundle that is found on H&E staining of the brain in the presence of long standing gliosis, occasional tumors, and some metabolic disorders. Have ubiquitin
Corporea Amylacia is…
Changes that happen in astrocytes that have a bigger, rounder appearance. Look like pearls. Just a degenerative change that you see in aging. don’t mean anything, but shouldn’t be confused with a tumor
What do microglia do when responding to injury?
Proliferate, develop long nuclei, form nodules around dead cells
