Brain Neurotransmitter Systems Flashcards
Of inhibitory or excitatory, which signal is more prominent?
Inhibitory (90%)
Hyperpolarization usually involves what kind of receptors?
G-protein
What does lidocaine do?
Blocks sodium channels and prevents signal propagation
What does DOPA do and what is it used to treat?
DOPA is an intermediate product between tyrosine and dopamine, it is used to treat Parkinsons
What does reserpine do?
Depletes neurotransmitter stores, specifically norepinephrine
What do monamine oxidase inhibitors do?
Prevent metabolism of neurotransmitters
What does methamphetamine do?
Increases release of neurotransmitters
What does cocaine do?
Prevents dopamine reuptake into presynaptic terminals
Pathways that are aligned linearly for sensory perception or motor control are called…
Hierarchical systems
Neurological systems that spread out and do not follow a direct path are called
diffuse systems
What types of neurotransmitters are found in hierarchical systems?
Glutamate, GABA, glycine
What types of neurotransmitters are associated with diffuse systems?
acetylcholine dopamine norepinephrine serotonin cannabinoids opiates
What are the three types of receptors for glutamate?
NMDA (Ca, Na and K), AMPA (Na & K), Kainic acid (Na &K)
Does GABA inhibit or excite postsynaptic neurons?
inhibit
Does glutamate inhibit or excite presynaptic neurons?
inhibit
What is the difference between GABAa and GABAb?
GABAa is a chloride channel, GABAb is a metabotropic receptor that augments K channels and inhibits Ca channels
What is glycine? Inhibitory or excitatory?
inhibitory
Which dopamine receptor is defective in Parkinson’s disease?
D2
Bipolar disorder and schizophrenia are associated with what kind of receptor?
5HT2a receptors (serotinin receptors)
