CNS Stimulants

Question 1

CNS Stimulants increase

Answer 1

alertness/awareness
productivity/motivation
arousal/locomotion, HR, BP
Euphoria
Nervousness/anxiety

Question 2

CNS Stimulants decrease

Answer 2

requirement for sleep and food intake

Question 3

CNS Stimulant overdose can cause (2)

Answer 3

convulsions

death

Question 4

Doxapram - drug type?

increases? (2)

two major characteristics?

Answer 4

respiratory stimulant

counteracts post-anesthetic respiratory depression

increases tidal volume and respiratory rate

fast acting, short duration

Question 5

analeptics and respiratory stimulant

Answer 5

Doxapram

Question 6

Analeptics and respiratory stimulants MOA

Answer 6

ANTAGONIST to GABA-a receptors

Question 7

Methylxanthines (2)

Answer 7

caffeine

theophylline

Question 8

Caffeine primary treatment for?

Answer 8

apnea of prematurity

Question 9

Theophyllin primarily used for (2)

Answer 9

COPD and Asthma

Question 10

Sympathomimetic Amides (6)

Answer 10

Methamphetamine
Dexamphetamine
Methylphenidate
Cocaine

Modafinil
Atomoxetine

Question 11

CNS Stimulants Metabolism (2)

Drug-Drug interactions (2)

Answer 11

peripheral degradation by MAO enzymes

Liver degradation

Do not use with MAOI’s or SSRI’s

Question 12

CNS Stimulant excretion

Answer 12

in urine mostly unchanged

Question 13

Analeptic MOA

Answer 13

depression of inhibitory neurotransmission

disinhibition

Question 14

Methylxanthines MOA

Answer 14

inhibition of CNS Suppression

Question 15

Amphetamines, Cocaine MOA

Answer 15

enhancement of excitatory transmission

inhibition of DOPAMINE TRANSPORTER

as well as SERT AND NET

Amphetamine also interferes with VMAT AND VESICLE STORAGE

Question 16

Home of DA Neurons =

Answer 16

Ventral Tegmental Area

Question 17

Side Effects of Psychomotor Stimulants

Answer 17

euphoria, dysphoria, insomnia, irritability, tremor, headache, loss of appetite

MI, CVA

anorexia, weight loss

addiction

Question 18

ADHD
hyperactivity/impulsivity type prevalance?

inattentive predominant type?

combined type?

Answer 18

10%

30 to 40%

50 to 60%

Question 19

Non-Stimulant ADHD Tx

Answer 19

Atomoxetine
Clonidine
Modafinil
Antidepressants

Question 20

Atomoxetine MOA

Answer 20

selective NE RE-UPTAKE INHIBITOR

Question 21

Modafinil MOA

clinical use?

Answer 21

histamine neuron activator in the TUBEROMAMMILLARY NUCLEUS of the hypothalamus

promotes attention and awakeness

NARCOLEPSY