Anti-Psychotics Flashcards
Psychosis
variety of mental disorders with multiple causes and manifestations
disturbances in behavior and thought processing
DELUSIONS
HALLUCINATIONS
Schizophrenia
SEVERE TYPE OF PSYCHOSIS
neurodevelopmental disorder
genetic disorder with high heritability
Schizophrenia Positive Symptoms
manifestation of ABNORMAL BEHAVIOR
delusions, hallucinations, agitation, paranoia, etc.
Schizophrenia Negative Symptoms
ABSENCE OF NORMAL BEHAVIOR
emotional apathy, socially withdrawn, inattentiveness
Primary Pathophysiology of Schizophrenia
Hyperactivity of mesolimbic/mesocortical DA system
EXCESSIVE LIMBIC DA ACTIVITY
leads to psycosis
anti-psychotics STRONGLY BLOCK D2 receptors
Other Pathophysiology Theories
Serotonin Hypothesis –> 5HT-2A
GLutamate Hypothesis –> hypofunction of NMDA receptors
Anti-psychotics Main Goal
REDUCE PSYCHOTIC SYMPTOMS
Neuroleptics
high incidence of ??
subtype of anti-psychotic –> produces HIGH INCIDENCE OF EXTRAPYRAMIDAL SIDE EFFECTS
Two types of anti-psychotics
Which are now most widely used?
TYPICAL
ATYPICAL
ATYPICAL most widely used
Some therapeutic indications (4)
Schizophrenia
Psychotic behavior
Severe Mania
Anti-emetic
Typical Anti-Psychotics (4)
Chlorpromazine
Thioridazine
Fluphenazine
Haloperidol
Atypical Anti-Psychotics (6)
Clozapine Olanzapine Risperidone Aripiprazole Quetiapine Ziprasidone
Most potent TYPICAL anti-psychotic
Least potent
Fluphenazine/Prochorperazine
Chlorpromazine
Many ATYPICAL AGENTS produce what?
ACTIVE METABOLITES
d/t CYP450 metabolism
MOA of Anti-psychotic Agents
Atypical agents have what other quality?
MOST ARE DOPAMINE RECEPTOR ANTAGONIST
Atypical also INHIBIT 5-HT-2A AND D2 RECEPTORS
