CNS Stimulant And aDHd Flashcards
What type of drugs should CNS stimulant avoid?
Any drugs that increase level of monoamines: avoid MAO I and SSR I agents
inhibit CNS suppressant and is a respiratory stimulant
Methylxanthine
which drug is used as the PRIMARY tx for apnea of prematurity
Caffeine
Theophylline
relaxes bronchial smooth muscle
Use COPD, asthma, apnea of prematurity
Psychomotor stimulant
Amphetamine Methamphetamine Dexamephetamine Methylphenidate Cocaine MDMA "ectasy" Modafinil Atoxmoxetine
Metabolism/excretion of CNS stimulants
Degraded by MAO-A and MAOB–>metabolized by liver–>active metabolites
Excreted in urine
how long is the duration of CNS Stimulant
SHORT duration, requires multiple dosing or extended release formula
inhibit GABA and glycine antagonists
Analeptic stimulants (doxapram)
which CNS stimulant cause enhancement of excitatory transmission–>increase catecholamine levels
Amphetamine, Cocaine
Which CNS stimulant enhance excitatory transmission by selective NE transporter BLOCKADE
Atoxmoxetine
ADHD tx
methylphenidate#1
Amphetamine
dextroamphetamine
Non stimulant: Atomoxetine Clonidine Modafinil (not approved) antidepressants
Drug-induced and postanesthesia respiratory depression tx
Doxapram
Performance enhancement
amphetamine, caffeine
Narcolpesy and sleep disorder tx
Modafinil**, amphetamine, dextroamphetamine, ephedrine, methphenidate
what drug is used as anorexiants for obesity?
amphetamine, dextroampehtamine
what is a major side effect to cocaine, other side effects?
severe weight loss
other:
CNS: euphoria, dysphoria, insonmia, irritability, tremor, headache, loss of aapetite
Cardio: MI, stroke
what are some cardio side effects to cocaine
MI and stroke
two types of symptoms for ADHD
inattention and impulsitivity/hyperactivity
sympathomimetic effect
mydriasis, tachycardia, HTN
what is amphetamine legally used for
narcolepsy, ADHD, short term weight loss
Cocaine MOA
inhibits dopamine transporter to increase DA in synaptic cleft
what part of the brain is affected with ADHD
dorsal lateral prefronal cotex lacks dopaine
dextroamphetamine tx
ADHD, obesity, narcolepsy
drug tx obesity? and MOA?
orlistat: lipase inhibitor. decrease GI fat absorption
