CNS/Sensory Flashcards
What are spinal nerves responsible for?
Somatic sensation:
Touch
Temperature
Pain
What is the afferent system?
Sensory input, cell bodies out of CNS (axons out of CNS)
Efferent
Motor output
Cell bodies in CNS
What are the cranial nerves?
Somatic, visual, olfactory, taste, auditory, vestibular
Where do cranial nerves project to?
Brainstem or other parts of the brain
What is the motor output of the CNS called
Efferent (motor output)
Spinal Nerves functions
Somatic sensation
- touch
- temperature
- pain
What are somatic efferent nerves?
Innervate skeletal muscle, only excitatory, motor neurons
What are autonomic efferent part of nervous system do?
Innervates interneurons, smooth and cardiac muscle, excitatory and inhibitory (enteric nervous system)
What is the white matter in the spinal cord?
Axons running up and down the spinal cord
What is the purpose of the central canal?
Allow CSF to flow
Where are the cell bodies of the efferent neurons found?
In the gray matter
Where are the cell bodies of the neurons whose axons carry afferent signals into spinal cord?
In the dorsal root, more specifically dorsal root ganglion
How many cranial nerves are there?
12
How many cranial nerves enter or leave the brain stem?
10 (pairs, one per side) of 12
What are the only two nerves that do not enter or leave the brain stem called?
Olfactory and optic nerves
Steps of Nervous System development
- Fertilized egg (ovum)
- Ball of cells
- Blastocyst (week 1)
- Blastocyst (week 2)
- Blastocyst (week 3)
- Week 3
Week 1 Blastocyst develops
inner cell mass
Week 3 Blastocyst develops
embryonic disk
neural plate
What are the three layers that make up the embryonic disk, and their location.
Ectoderm (outermost layer)
Mesoderm (middle)
Endoderm (inner)
Neural groove
a shallow median groove of the neural plate between the neural folds of an embryo
What develops in week 4 of the neural tube
vesicles
Neural Crest becomes part of
PNS
Neural tube becomes
CNS and part of PNS
Neural Tube is composed of
Forebrain, Midbrain, Hindbrain
Forebrain becomes
Cerebal hemispheres and Thalamus
Midbrain becomes
Midbrain
Hindbrain becomes
Cerebellum, pons, medulla
Rest of Neural tube becomes
Spinal cord
Cavity becomes
the ventricles and central canal
What do ventricles contain (+amount)
150 ml of cerebral spinal fluid (CSF)
Where is CSF produced, and how much per day?
Produced in the choroid plexus (in the four ventricles, but mainly the two laterals), 500 ml/day
Describe the general composition of CSF?
Sterile, colorless, acellular fluid that contains glucose
Cerebrospinal spinal fluid function
1) Supports and cushions the CNS. Specific gravity of CSF and the brain are equal.
2) Provides nourishment to the brain.
3) Removes metabolic waste through
absorption at the arachnoid villi.
How is CSF circulated?
Passively , not pumped
Where does CSF enter?
The subarachnoid space
Hydrocephalus
an abnormal buildup of fluid in the ventricles (cavities) deep within the brain
Communicating Hydrocephalus
The flow of CSF is blocked after it exits the ventricles
Noncommunicating Hydrocephalus
The flow of (CSF) is blocked along one or more of the narrow passages connecting the ventricles.
Meninges cover the ____ and _____ ____
brain and spinal cord
What are the 3 meninges (membrane) of the CNS?
Dura mater, Arachnoid membrane, Pia mater
Where does CSF return to the blood?
at the dural sinus
What substrate is metabolized by the brain?
Usually only glucose
T/F: There is a lot of glycogen in the brain
F: Very little glycogen in the brain.
What does the brain need continuous supply of? (2)
glucose and oxygen
Glucose transport into the brain does not require ____
insulin
A few seconds of blood supply interruption can lead to
loss of consciousness
A few minutes of blood supply interruption can lead to
neuronal death (stroke)
What % of blood in circulation does the brain receive?
15%
Brain is __% of total mass
2
What is the use of the circle of willis?
SAFETY FACTOR - Able to ensure there is constant supply of blood to brain by ensuring that if one side is compromised, there is necessary blood flow.
CSF moves from
______ to _____ through _____ to _____ through _____ to _____ to _____ back to _____
Heart
Chorioid plexus
ventricles subarachnoid space archnoid villi dural sinus venous system Heart
Blood moves from
______ to either _____ arteries or _____ arteries.
The _____ arteries moves straight to _____ whereas the ______ arteries moves through _____ to _____. Then to the _____ to the ______ system back to _____
Heart
vertebral arteries
carotid arteries carotid arteries circle of willis vertebral arteries basilar artery circle of willis brain venous system heart
Blood-brain barrier
capillary wall
Function of astrocytes (glia) (4)
- provide strucutral support
- induce tight juctions
- glutamate K+
- phagocytosis of debris
Sensation
Awareness of sensory stimulation.
Perception
The understanding of a sensation’s meaning
T/F: We perceive energy of a sensory stimulus directly
F: We do not perceive the “energy” of a sensory stimulus directly.
T/F: We only perceive the neural activity that is produced by sensory stimulation.
T: We only perceive the neural activity that is produced by sensory stimulation.
How do tight junctions impact the effects of the capillary wall of endothelial cells?
It heavily controls diffusion of things across capillary wall
What properties do drugs need to be able to move from blood to extracellular space?
Lipid-soluble or hitch a ride with active transport mechanism
What is the law of specific nerve energies?
Regardless of how a sensory receptor is activated, the sensation felt corresponds to that of which the receptor is specialized
What is the law of projection?
Regardless of where in the brain you stimulate a sensory pathway, the sensation is always felt at the sensory receptor location
(Law of specific nerve energies/projection):
Rub your eyes hard and you will see light.
Law of specific nerve energies
Penfield electrically stimulated somatic sensory cortex and patients perceived somatic sensation in the body
Law of projection
(Law of specific nerve energies/projection): Phantom limb pain after amputation.
Law of projection:
What is the labeled line principle?
The brain knows the modality and location of every sensory afferent
6 sensory systems:
Visual, Auditory, Vestibular, Somatosensory, Gustatory, Olfactory
Modality of Vestibular
Balance
Modality of Somatosensory
Somatic Senses
4 Somatic Senses
Touch
Pain
Proprioception
Thermal
Taste stimulates
Sweet
Sour
Salt
Bitter
Umani
Stimulus Energy of Somatosensory system
Mechnical, thermal, chemical
Stimulus Energy of Vestibular sensory system
Gravity, Acceleration
What is transduction?
Transduction in the nervous system typically refers to stimulus-alerting events wherein a physical stimulus is converted into an action potential, which is transmitted along axons towards the central nervous system for integration
What is responsible for the different afferent responses to constant stimulation?
Because of adaptation where non changing stimulus does not lead to constant stimulus (ie putting clothes on in the morning and not feeling them after a while)
Stimulus Energy of Gustatory sensory system
Chemical
Stimulus Energy of Olfactory sensory system
Chemical
Receptor class of Visual sensory system
Photorecptors
Receptor class of Auditory sensory system
Mechanoreceptors