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PATH MAGIC > CNS PATHOLOGY 1 > Flashcards

CNS PATHOLOGY 1 Flashcards

1
Q

cells involved in JC virus infection?

A

oligodendrocyte

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2
Q

mech of PML (progressive multifocal leukoencephalopathy)?

A
  • demyelination of CNS due to destruction of oligodendrocytes - associated with JC virus - rapidly progressive
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3
Q

2 structures from neural crest?

A
  1. PNS neurons 2. Schwann cells
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4
Q

structure from mesoderm?

A

microglia

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5
Q

what pathology is associated with hyperphosphorylated tau protein?

A

Alzheimer

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6
Q

what pathology is associated with silver staining spherical tau protein with an aggressive change in behavior?

A

Frontotemporal dementia (Pick’s dz)

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7
Q

what path is associated with alpha synuclein defect with visual hallucination?

A

Lewy body dementia

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8
Q

is ACh increased or decreased in Alzheimer?

A

decreased

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9
Q

what is the cause for communicating hydrocephalus?

A

decreased CSF absorption by arachnoid granulations

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10
Q

what 2 structures make CSF?

A
  1. ependymal cells 2. choroid plexus
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11
Q

what condition is associated with arachnoid scarring post-pyogenic meningitis?

A

communicating hydrocephalus

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12
Q

what is normal pressure hydrocephalus?

A
  1. affects elderly 2. CSF pressue elevated only episodically 3. no increased subarachnoid space volume 4. expansion of ventricles –> distorts fibers of corona radiata
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13
Q

what is the mech of clinical symptoms in normal pressure hydrocephalus?

A

expansion of ventricles –> distorts fibers of corona radiata leading to urinary incontinence, ataxia, cognitive dysfunction

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14
Q

mechanism of ex vacuo hydrocephalous

A

the appearance of inc CSF due to decreased brain tissue is seen in Alzheimer diseases etc

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15
Q

is ICP increased or decreased in communicating hydrocephalus?

A

increased

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16
Q

Pyogenic meningitis- CSF

A

Low sugar, increased protein and high pressure

17
Q

Aseptic meningitis

A

Normal sugar, increased protein and high pressure

18
Q

HIV with dementia and motor defect- biopsy

A

microglial nodule

19
Q

Repair of the brain- which cell

A

astrocytes

20
Q

Viral meningitis- prognosis

A

dementia

21
Q

hemorrhagic meningitis

A

herpes

PATH MAGIC (21 decks)

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