CNS Neuropharmacology Flashcards
What precursors, key enzymes, and transporter are used in the production and storage of glutamate?
Glutamate is formed from Glutamine by Glutaminase. It is taken up by the neuronal or glial glutamate transporter [Gt(n) or Gt(g), respectively]
What precursors, key enzymes, and transporter are used in the production and storage of GABA?
GABA is formed from Glutamate by GAD (glutamic acid decarboxylate). It is taken up by the GABA transporter.
What are the chief NTs in the hierarchical CNS systems?
Glutamate and GABA
What are the chief NTs in the diffuse CNS systems?
ACh, Dopamine (DA), Norepinephrine (NE), Serotonin (5HT)
What precursors, key enzymes, and transporter are used in the production and storage of ACh?
ACh is formed from Acetyl-CoA and Choline by choline acetyl transferase (CAT). Choline is taken up by the neuron in the rate limiting step. ACh is taken up into storage vesicles by the Vesicle Associated Transporter (VAT).
What precursors, key enzymes, and transporter are used in the production and storage of Dopamine?
Dopamine is formed from Tyrosine via Tyrosine Hydroxylase -> L-Dopa and then Dopa decarboxylase -> Dopamine. Dopamine is taken up into vesicles by Vesicular Monoamine Transporter (VMAT) and protected from degradation by Monoamine Oxidase (MAO).
What precursors, key enzymes, and transporter are used in the production and storage of Norepinephrine?
Noepeinephrine is formed from Tyrosine by the Dopamine pathway and then Dopamine-beta-Monooxygenase (DbH). It is taken up into vesicles by Vesicular Monoamine Transporter (VMAT) and protected from degradation by Monoamine oxidase (MAO).
What precursors, key enzymes, and transporter are used in the production and storage of Serotonin?
Serotonin (5HT) is formed from Tryptophan by Tryptophan Hydroxylase (TpH) -> 5-OH-tryptophan and then AAA decarboxylase -> 5HT. It is taken up into vesicles by Vesicular Monoamine Transporter (VMAT) and protected from degradation by Monoamine oxidase (MAO).
