CNS - neurones, NTs and synapses Flashcards
what are ions
electrically charged chemicals
example of positive ion
sodium (Na+)
example of negative ion
chloride (Cl-)
what are the charges inside and out of a neurone at rest
negative on inside
positive on outside
resting potential of a neurone
-70mV
what is an action potential
a spike in electric charge in an axon caused by sodium ions crossing the cell membrane - created by depolarising current
how does a stimulus cause an action potential
- causes resting potential to move towards being more positive
- reaches threshold of -55mV so ion channels open
- positive ions diffuse in down electrochemical gradient
- neurone grows more positive and depolarised
what is the result of depolarisation and action potential
electrical impulse fires across neurone away from cell body and towards to axon terminal then returns to resting
how does synaptic transmission work
- presynaptic neurone excited by action potential
- vesicles containing NT fuse with presynaptic membrane
- NTs enter synaptic cleft
- they bind to receptors on postsynaptic neurone, this activates the next neurone
- some NTs then leave the cleft by diffusion, reuptake back into presynaptic neurone or are broken down by enymes
examples of NTs
dopamine
glutamate
serotonin
dopamine
pleasure and addiction
influences motivation and reward pathway
high/low levels can cause SZ
glutamate
cognitive function
memory and learning
excess can cause cell death, then alzheimers/strokes/seizures
serotonin
happiness and mood
more serotonin, less depressed
what makes up the CNS
brain + spinal cord
frontal lobe
at the front
thinking/problem solving
parietal lobe
at the top
perception
temporal lobe
at the bottom
memory/language
occipital lobe
at the back
visual processing
cerebellum
coordination
brain stem
regulates heart rate and body temperature
limbic system
hypothalamus
hippocampus
amygdala
hypothalamus
homeostasis
regulates hormones and emotions
hippocampus
converts STM to LTM
left amygdala
motivation and reward
right amygdala
fear conditioning