CNS Intro II Flashcards
(23 cards)
Metabotropic
receptors affect ion channels indirectly via second messenger
Ionotropic
receptors affect ion channels directly
At the pre-synaptic terminal Ca+ influx causes
neurotransmitter-filled vesicle to fuse with the cell membrane
Axo-axonic synapse is inhibitory. T or F
False, it can be inhibitory or stimulatory
Direct Gating
Ionotropic receptors - neurotransmitters binds to receptor on the channel causing gate to open
Which receptor, metabotropic of ionotropic, produce a faster action (msec)?
Ionotropic
metabotropic receptors are involved in
modulating behaviours by altering the excitability of neurons and strength of synaptic connections
ionotropic receptors are involved in
neural circuitry that produces behaviour
Indirect Gating
Metabotropic receptors - neurotransmitters bind to receptors that are distant to the ion channel itself and uses a second messenger to open/close the gate
A neuron can contain up to two types of neurotransmitters. T or F
Fasle, each neuron contains only one type of neurotransmitters but can have a co-transmitter
What is a co-transmitter
Substance that are involved in neurotransmission but do not have all properties of neurotransmitters
Autoreceptors
Provide feedback regulation of neurotransmitter release based on the concentration of transmitters in the synapse
Substance P receptor
NK-1
Glutamate receptor
NMDA and others
Which NT are involved in alzheimer’s disease?
ACh and Glutamate
Which NT are involved in anxiety?
GABA and 5HT
Which NT are involved in depression?
5HT and noradrenaline
Which NT are involved in epilepsy?
GABA and Glutamate
Which NT are involved in migraine?
5HT and CGRP
Which NT are involved in pain?
mu, NK-1, CB1 and CB2
Which NT are involved in parkinson’s disease?
Dopamine, ACh, glutamate
Which NT are involved in schizophrenia?
Dopamine
Autoreceptors are found pre-synaptically, post synaptically or at both sites?
Presynaptically
