CNS Infections- Human Parechovirus

Question 1

Thought the be the most common viral cause of meningoencephalitis in young infants and the most frequent single viral agent causing neonatal sepsis/meningitis in summer-autumn seasons since 2005

Answer 1

HPeV3

Question 2

There are 16 to 17 HPeV genotypes, but ______ and ______ are the most prevalent strains.

Answer 2

HPeV1 and HPeV3

HPeV1’s wide genetic variability led to further division into 2 clades: HPeV1A and HPeV1B

Question 3

HPeV3 is seen mostly in _______

HPeV1 is seen mostly in _______

Answer 3

3- infants

Question 4

Presenting symptoms are consistent with sepsis-like illness, meningitis, or a nonspecific febrile illness. Presentations in which HPeV3 should be suspected include ___________.

Answer 4

neonatal seizure and neonatal sepsis

Question 5

For diagnosis, HPeV3 confirmation is by __________

Answer 5

reverse transcription polymerase chain reaction (RT-PCR) of cerebrospinal fluid (CSF) or, less often, serum.

Question 6

RT-PCR–positive CSF usually lacks _________

Answer 6

pleocytosis

Question 7

PERIPHERAL _____________ are common

Answer 7

leukopenia/lymphopenia and modestly increased C-reactive protein levels

(liver dysfunction or other laboratory abnormalities are uncommon)

Question 8

Mortality/sequelae are rare, but if they occur, they follow ________

Answer 8

difficult–to-control seizures