CNS I

Question 1

ACh- origin, function, disease if too little?

Answer 1

widespread, excitatory, dementia (Alzheimer’s)

Question 2

Glutamate- origin, function, disease if hyperactive?

Answer 2

origin- thalamus, subthalamic nucleus
function- excitatory
disease- epilepsy, excitotoxicity

Question 3

GABA & Glycine- origin, function, neuropharmacology?

Answer 3

origin- widespread (interneurons)
function- inhibitory
used as sedative hypnotics, anxiolytics, anticonvulsants, muscle relaxants

Question 4

NE- origin, function, neuropharmacology?

Answer 4

origin- locus ceoruleus
function- emotion, arousal, fear/anxiety/stress
neuropharm- used in antidepressants, ADHD, narcolepsy

Question 5

DA- origin, projection, function, neuropharmacology?

Answer 5

origin- substantia nigra
projection- basal ganglia, prefrontal cortex, limbic system
function- voluntary movement, behavior, neuroendocrine secretion
neuropharm- too little= parkinsons; too much= psychosis & hyperprolactinemia

Question 6

Serotonin- origin, function, neuropharmacology

Answer 6

origin- raphe nuclei
function- emotion (mood), sleep
neuropharm- too little= depression; too much=hallucinations

Question 7

Histamine- origin, function, neuropharmacology?

Answer 7

origin- tuberomammillary nucleus
function- wakefullness, motion
neuropharm- sedation, allergies, motion sickness