CNS Drugs

Question 1

Tetrodotoxin

Answer 1

Na channel blockers found in pufferfish

Question 2

a-bungarotoxin

Answer 2

Antagonist to nicotinic ACh receptor

Question 3

Picrotoxin

Answer 3

GABAa receptor antagonist found in Anamirta cocculus

Question 4

Strychnine

Answer 4

Glycine receptor inhibitor found in an Indian plant

Question 5

Ketamine

Answer 5

Glutamate antagonist used as a rapidly acting antidepressant

Question 6

Cocaine

Answer 6

A hell of a drug (Rick James voice)

Also, a NE reuptake transporter blocker

Question 7

Desipramine

Answer 7

NE reuptake inhibitor that is a trycyclic antidepressant

Question 8

Maprotyline

Answer 8

Tetracyclic antidepressant that inhibits NE reuptake

Question 9

Protryptiline

Answer 9

SNRI that is a tricyclic antidepressant and also used to treat ADHD

Question 10

Reserpine

Answer 10

Disrupts vesicles containing DA and NE, inhibiting their release

Question 11

Guanethedine

Answer 11

Displaces NE from vesicles, inhibiting its release

Was used for HT

Question 12

Sinemet

Answer 12

Combo of L-dopa and carbidopa used to treat Parkinson’s

Question 13

Spiroperidol, pimozide, haloperidol

Answer 13

DA2 receptor antagonists used as antipsychotics

Question 14

Raphe magnus

Answer 14

Main 5-HT producing nucleus of the CNS

Question 15

Major projection sites for Serotonin

Answer 15

Hypothalamus, cortex, subiculum

Question 16

Fluoxetine, escitalopram, fluvoxamine, paroxetine, trazodone, imipramine

Answer 16

SSRI used to treat depression

Question 17

Barbiturates

Answer 17

Bind to GABAa and stimulate Cl- influx, leading to inhibitory actions

Question 18

Benzodiazepines

Answer 18

Bind to GABAa; sedative and hypnotic

Question 19

Muscarine

Answer 19

M1 receptor agonist

Question 20

bromocriptine

Answer 20

D2 receptor agonist used to treat Parkinson’s and hyperprolactinemia