Anticancer Drugs

Question 1

Dolasetron, Granisetron, Ondansetron

Answer 1

Serotonin-receptor antagonists. Management of N & V associated w/ radiotherapy or chemotherapy. First-line antiemetic therapy.

Question 2

Prochlorperazine, Fluphenazine, Chlorpromazine

Answer 2

Antidopaminergics that selectively depress the Chemoreceptor Trigger Zone (CTZ) and, to a lesser extent, the Vomiting Center. Second line drugs to treat N & V associated w/ chemotherapy.

Question 3

Anticancer agents susceptible to MDR-1-mediated resistance

Answer 3

Anthracyclines
Vinca alkaloids
Paclitaxel (Taxol)
Etoposide
Mitomycin (Mutamycin)
Plicamycin (Mithramycin)