CNS DEPRESSANTS Flashcards
SEDATTIVES
CNS will inhibit them -
CNS DEPERSSANTS
think of ALCHOL
HYPONTICS
make you sleepy more potent effect on CNS , meant to cause SLEEP
SEDATIVE-HYPONTIC
Dose dependent small doses chill you out high dose will SLEEP
- Barbiturates
- Benzos
- Miscalleneous drugs
SLEEP
cyclir repeptative unware or sensory stimuli of immediated envoiroment , not conciusly aware
SLEEP ARCHITETURES
RAPID EYE( REM) Non - REM sleep
BENZODIAZEPINES
sedative hypnotic drugs now we go for non benzodiazepine
Sedative hypnotic
Anziolytic- decrease anxity
BENZO: SEDATIVE HYPNOTIC
long acting: CLONZEPAM (klnopan) DIAZEPAM (Valium) Intermediate acting (alprazpam- Xanax LORAZEPAN Ativan Short acting: zolpidem(AMbien) Midazolam(Versed) Lunseda
BENZO: MECHANSIM OF ACTION
depress CNS
GABA
don’t suppress rapid eye movement effect Quality of sleep (don’t increase metabolism of other drugs)
decrease of interactions
BENZO: DRUG EFFECTS
induce sleep , relax and agitation inducing USE FOR SKELTAL PAIN
BENZO: INDICATIONS
HELP FALL ASLEEP , SEDATION MUSCLE RELXERS ANXIETY, VERSCED(ACUTE SEIZURE) CIWA BALANCE ANETHESIA CONCIOUS SEDATION (BONE RESETTING COLONSCOPY)
BENSO: SIDE AFFECT
HEADACHE DROWISNESS DIZZNESS DAY TIME HANG OVER EFFECT SLEEPINES (FALL RISK)
BENZO: TOXICITY OVERDOSE AND INTERACTIONS
CONFUSION SOMOLENCE COMA DIMINISHED REFLEX BENZO WITH ALOCHOL = RESPIRATORY DEPRESSION
FLUMAZENIL IS ANTIDOTE
INTERACT WITH ANITFUNGIL ABT , GRAPEFRUIT JUICE INTERACT WITH OTHER CNS DEPPRESANTS, RIFAMPIN
DIAZEPMA (VALIUM)
ANXIETY OR MUSCLE RELAXER
MIDAXOLAM(VERSED)
AGIGATION AND SEDATION (ORHTO PROCEDURES
)INJECTION IN ADULTS RECTALLY IN KIDS OR LIQUID
TEMAZEPAM RESTORIL
takes a while to work take an 1hour before you go to bed
LUNESTA: nonbenzo
need 8 hours of sleep time if need to wake uo in 6 hours then shouldnt take
RAMELTEON(ROZEREM): NONBENZO
NOT KEEP ASLEEP HELP FALL ASLEEP
ZALEPHON: SONAATA
ONLY WORKS 4 HOURS
ZOLPIDEM(AMBIEN)
SHORT ACTING : NOT DAYTIME SLEEPINESS ONE NOW AND RELEASES SOME LATER
CAUSES SLEEP WALKING
KAVA
HELP FALL ASLEEP CAN CAUSE YOU TO TURN YELLOW DONT TAKE IF HAVE LIVER IMPARIMENT
VALERIAN
CAN CAUSE RESTLESSNES AND ANXITY INTERACTS WITH MAOI ALCHOL INTERACTS WITH LIVER ADN CARDIAC ISSUES (yellow skin) may cause insomnia
BARBITURES
STANDARD - HABIT FORMING DOSENT TAKE ALLOT FOR THEM TO WORK
work in the brain stem inhibit nerve stem from geeting in the brain
Drug effects: high doses lower RESPITORY RATE
stimulate liver enzymes (drugs don’t last as long in system)
low therapeutic index: the effective safe dosage range is narrow only a little bit before the become toxic
BARBITUES INDICATIONS
sedatives anticonvulsants seizures 1. ultrashort- surgical procedures short acting - sedation convulsant intermediate sedation and convulsant long acting - sleep induction and seizures
