CNS dementia

Question 1

DEMENTIA

Alleviated by?

Answer 1

Increasing amount of acetylcholine ACh

Question 2

MILD-MODERATE DEMENTIA is tx with which AChEIs

DR.G

Answer 2

Donepezil-
Rivastigmine-
Galantamine-

Question 3

SEs of donepezil

Answer 3

neuroleptic malignant syndrome

life threatening!
mental state changes, rigidity, fever, autonomic dysfunction

Question 4

SEs of rivastigmine

Answer 4

GI side-effects (less in transdermal formulation)
use patch instead

Question 5

SEs of Galantamine

Answer 5

S-J syndrome (skin reaction, rash)

Question 6

what drug used to treat MODERATE-SEVERE DEMENTIA?

Answer 6

Memantine

Question 7

how is AGGRAVATION TREATED W/? 2 drug classes

Answer 7

Benzodiazepine/Antipsychotics i.e. risperidone

Question 8

INCREASED ACETYLCHOLINE-> PARASYMPATHETIC SIDE-EFFECTS?
DUMB BELS

Symp- fight/flight
Parasymp- rest/digest

Answer 8

Diarrhoea
Urinary Incontinence
Muscle Weakness
Bradycardia
Bronchospasms
Emesis
Lacrimation
Salivation
Stop treatment, treat the dehydration before reinitiating and amend the dose if need be