CNS Blood Supply Lecture Flashcards
Blood carries
O2 and glucose
T or F: Brain cells have no energy stores of their own
TRUE
Brain consumes what percentage of the total energy generated in the body
15 to 20%
Brain is vulnerable to an energy crisis! Can be from what
Hypoxia (altitude, CO poisoning)
Hypoglycemia
Severe anemia
Drop in cerebral perfusion
Drop in cerebral perfusion can lead to
Global ischemia - cardiac arrest, shock, hypoxic ischemic encephalopathy
Local ischemia
Ischemia
Inadequate blood supply = reduced perfusion
HIE - Hypoxic ischemic encephalopathy - Preterm/Premature infants
Organs (still developing) can’t deliver enough O2 to brain
20% of babies born before 6.5 months gestational age
HIE - Term infants
Placenta abruption, umbilical cord problems, clotting of placental arteries
HIE - Death
learning and/or cognitive deficits
Cooling
Local ischemia - problem
lead to anoxia - lack of O2, lack of glucose
Temporary TIA
Prolonged can get neuronal death and then infarction
Causes of local ischemia
Occlusive (Thrombus, Embolus)
Hemorrhage (can occur at surface of brain or inside the brain matter)
Anterior brain blood supply - anterior circulation
Internal carotid artery
Posterior brain blood supply - posterior circulation
Vertebral artery
Anterior circulation -
Common carotid
Internal carotid/External carotid (face and neck)
Anterior circulation - internal carotid
Carotid foramen, penetrates the dura
Anterior cerebral
Middle cerebral
BOTH have cortical branches and deep penetrating branches - GRAY AND WHITE matter
Anterior circulation/Internal Carotid - ACA Gray and white matter of what
Inferior frontal lobe
Medial surface of frontal/parietal
Anterior corpus callosum
Anterior circulation/Internal Carotid - MCA Gray and white matter of what
Hemispheric convexity
Lateral portions of frontal, parietal, temporal, some occipital
PL of internal capsule
BG
Posterior circulation - Vertebrobasilar
Subclavian artery
Vertebral arter