CNS

Question 1

Group of drugs that are widely used anxiolytic drugs

Answer 1

Benzodiazepines

Question 2

are safe and effective.

Answer 2

Benzodiazepine

Question 3

Benzodiazepines act on…………receptor

Answer 3

GABA

Question 4

GABA receptors are composed of

Answer 4

a ß, and γ subunits families.

Question 5

Act on BZD receptor it enhances GABAs effects lead to

Answer 5

influx of chloride ions lead to hyper polarization and inhibition of action potential

Question 6

Therapeutic Uses

Answer 6

1- anxiety disorders

2- Muscular disorders

3- Amnesia

4- Seizures

5- sleep disorder

Question 7

Long-acting agent prefer than short acting agent

Answer 7

it induce more abrupt and sever withdrawal reaction.

Question 8

anxiety disorders Reserved for

Answer 8

Reserved for continued severe anxiety and used for short period,

tolerance occur when use it 1-2 Wks

Question 9

Diazepam is

Answer 9

useful in muscular spasm such as muscle strain. Muscle spasticity as in multiple sclerosis and cerebral palsy. Diazepam is used in grand mal and status epilepticus & acute alcohol withdrawal. Reduce withdrawal related seizure.

Question 10

Clonazepam is

Answer 10

useful in abscent epelipsy.

Question 11

Diazepam is used in

Answer 11

grand mal and status epilepticus & acute alcohol withdrawal. Reduce withdrawal related seizure.

Question 12

Sleeping disorder All benzodiazepines have

Answer 12

sedative and calming effects but not all of them have hypnotic effects.

− They decrease the latency to sleep onset and increase stage two of nonREM sleep.