CMA prep July Flashcards
how many types of validity are there for animal models
3
what are the three types of validity criteria
construct
predictive
face
what is construct vailidity
similiar cause or pathophysiology between the human condition and animal model
what is predictive validity
treatments that are effective in animal models are also effective in human patients and vice versa
what is a translational task
train an animal to mimic a human test
what is naturalistic
use a relevant intrinsic or innate skill or preference of the animal
how do you measure fear
cued or contextual fear conditioning
how do you measure anxiety
elevated plus maze/elevated platform/light-dark maze/open field
how do you measure attention
attentional set-shifting task (wisconsin card sort task)
how do you measure depression
learned helflness/forced swim
how do you measure locomotor activity
activity box/open field
how do you measure locomotor coordination
rotarod, skilled reaching, balance beam
how do you measure sensory perception
von frey test, temperature sensitivity
in fear conditioning what does the amygdala used for
cued fear conditioning
what is the combination in amygdala and hippocampus in fear conditioning used for
contextual fear conditioning
what is used to measure schizophrenia, ADHD, Autism spectrum, frontotemporal dementia
attention
what is attentional set and cognitive flexibility used
rat/mouse must pay attention to either odour of bowl, texture of digging medium or texture of bowl covering and the correct strategy is switched frequently
what does the mouse have to choose between in attentional set and cognitive flexibility
food reward is buried
choose by:
odour of bowl contents
texture of bowl contents
texture of bowl outer covering
how do you induce depression/apathy/anhedonia
tail suspension test
forced swim test
how to measure anhedonia
sucrose preference test
how do you measure apathy
sucrose splash test
what is used to test for parkinson’s or MND
locomotor activity
(activity box/open field)
how do you measure Huntinton’s or MS
locomotor coordination
rotarod, balance beam, skilled reaching
how fo you measure pain sensitivity in parkinson’s or chronic pain
sensory/pain perception
von frey test, temperature sensitivity
