CM 14.6 strain

Question 1

Syrian hamster use in science

Answer 1

o Model of dystrophic myocardial and skeletal muscle dz
o Bio 14.6 strain

Question 2

Etiology of CM 14.6 strain

Answer 2

o Ca2+ overload of myocytes
 ↑# of Ca2+ channels early in dz course
 ↑ free radicals → may participate in Ca2+ accumulation/cell injury
o ↑α1 and β-R in late stages

Question 3

Lesions and stages of developement

Answer 3

myocytolytic lesions begin to form at 30days/o
o 4 stages of development
 1: 30-60 days → onset of myocytolysis and necrosis
 2: fibrosis and Ca2+ deposition scars
 3: reactive hypertrophy of unaffected myocytes
 4: ↓ myocardial fct → CHF → death

Question 4

What drug protect against myocardial damage and how

Answer 4

Verapamil

o Inhibit voltage dependent Ca2+ cannels → ↓ Ca2+ uptake
o Prevent  injury by free radicals
 ↓ % areas of myocardial fibrosis/calcification