Clusters of Differentiation (CD) Markers

Question 1

CD 2

Answer 1

• T cells & some NK,
• CD58 CD59 ligand,
• involved in ALL & T cell lymphoma

Question 2

CD 3

Answer 2

• T cell receptor

Question 3

CD 4

Answer 3

• T cell receptor for MHC Class II

- HIV receptor

Question 4

CD 8

Answer 4

• T cell receptor for MHC Class I

Question 5

CD 14

Answer 5

• Macrophage

- Receptor for LPS

Question 6

CD 16

Answer 6

• NK cells

Question 7

CD 19

Answer 7

• B cell

Question 8

CD 20

Answer 8

• B Cell Calcium Channel
• B Cell Leukemia
• Hairy cell
• CLL
• Tx: Rituximab

Question 9

CD 21

Answer 9

• B Cell

- EBV receptor

Question 10

CD 26

Answer 10

• DPP4 (Dipeptidyl peptidase-4)
• Degrades GLP-1
• MOA - Gliptins,
• MERS-CoV receptor

Question 11

CD 28

Answer 11

• T cells (ALL OF THEM)

Question 12

CD 40

Answer 12

• On APC
• On Macrophage
• Binds CD140L (CD 154)
• CD 40L on T cell binds B cell CD 40 receptor causing resting B cell activation
• Deficiency causes Hyper IgM syndrome

Question 13

CD 55

Answer 13

• Complement Decay-Accelerating Factor (DAF)

- inhibits MAC polymerization

Question 14

CD 56

Answer 14

• NK cells (more specific than CD 16)

Question 15

CD 59

Answer 15

• MAC-inhibitory protein (MAC-IP)
• Protectin
• Prevents C9 polymerization (MAC pore formation)

Question 16

CD 95

Answer 16

• FAS receptor
• Apoptosis
• TNF receptor
• Activates/Releases Caspase & Cytochrome C

Question 17

CD 120

Answer 17

• TNF receptor

Question 18

CD 154

Answer 18

• CD 40 ligand (CD 140L)

- Stimulates class switching (B cells)

Question 19

CD 195

Answer 19

• CCR5
• HIV receptor
• CCR5 Delta 32 mutation = HIV Resistance

Question 20

CD 220

Answer 20

• Insulin receptor