CLOZAPINE Flashcards
What is the primary use of clozapine?
Clozapine is primarily used to treat treatment-resistant schizophrenia.
True or False: Clozapine is the first-line treatment for schizophrenia.
False
What type of receptor does clozapine primarily act on?
Clozapine primarily acts on dopamine D2 and serotonin 5-HT2A receptors.
Fill in the blank: Clozapine is known to have a risk of _______ which requires regular monitoring of white blood cell counts.
agranulocytosis
List one common adverse effect of clozapine.
Sedation
What are the physiological effects of clozapine?
Clozapine can lead to sedation, weight gain, and metabolic syndrome.
Which neurotransmitter systems does clozapine affect?
Clozapine affects the dopaminergic, serotonergic, and noradrenergic systems.
True or False: Clozapine has a high risk of seizures compared to other antipsychotics.
True
What is the recommended monitoring frequency for patients on clozapine due to agranulocytosis risk?
Weekly for the first six months, then biweekly for the next six months, and monthly thereafter.
What is an important drug interaction to consider when prescribing clozapine?
Clozapine can interact with drugs that affect CYP1A2 enzyme activity.
Fill in the blank: Patients taking clozapine should be monitored for _______ due to its potential to induce metabolic changes.
weight gain
What is the effect of clozapine on suicidal behavior in patients with schizophrenia?
Clozapine has been shown to reduce the risk of suicidal behavior.
Multiple Choice: Which of the following is NOT a potential side effect of clozapine? A) Agranulocytosis B) Weight gain C) Hyperactivity D) Sedation
C) Hyperactivity
What is the mechanism of action of clozapine?
Clozapine acts as an antagonist at dopamine D2 and serotonin 5-HT2A receptors, among others.
True or False: Clozapine is effective in patients who have not responded to other antipsychotic medications.
True
