CLOZAPINE Flashcards
What is the primary use of clozapine?
Clozapine is primarily used to treat treatment-resistant schizophrenia.
True or False: Clozapine is the first-line treatment for schizophrenia.
False
What is the mechanism of action of clozapine?
Clozapine acts as an antagonist at dopamine D2 and serotonin 5-HT2A receptors.
Fill in the blank: Clozapine is known to have a risk of __________, which is a potentially life-threatening condition.
agranulocytosis
What are common adverse effects of clozapine?
Common adverse effects include sedation, hypersalivation, and weight gain.
Which receptor type does clozapine primarily target?
Clozapine primarily targets dopamine D2 and serotonin 5-HT2A receptors.
What is a serious physiological effect associated with clozapine use?
Clozapine can cause seizures, especially at higher doses.
Multiple Choice: Which of the following is a contraindication for clozapine use? A) History of seizures, B) Hypertension, C) Mild anxiety
A) History of seizures
True or False: Clozapine does not interact with other medications.
False
What type of drug interactions can occur with clozapine?
Clozapine can interact with drugs that affect its metabolism, such as CYP450 inhibitors and inducers.
What is the recommended monitoring for patients on clozapine?
Regular monitoring of white blood cell counts is recommended to prevent agranulocytosis.
Fill in the blank: Clozapine is often reserved for patients who do not respond to __________.
other antipsychotic medications
What is one of the unique benefits of clozapine compared to other antipsychotics?
Clozapine is effective in reducing suicidal behavior in patients with schizophrenia.
Multiple Choice: Which of the following is NOT a side effect of clozapine? A) Agranulocytosis, B) Weight gain, C) Insomnia
C) Insomnia
