clozapine Flashcards
1
Q
indication
A
schizophrenia unresponsive to other Tx of intolerant of it
2
Q
s/e of clozapine
A
AGRANULOCYTOSIS - need specialist monitoring
intestinal obstruction (constipation)
3
Q
what type of drugs can clozapine interact with
A
drugs that cause agranulocytosis and constipation
4
Q
dose adjustments with clozapine
A
if stop OR start smoking during Tx
tobacco smoke is an enzyme inducer, induces CYP450 enzymes
speeds up metabolism
if stop, removed and enzyme levels can change
5
Q
missed doses with clozapine
A
doses missed for >48hrs RE-TITRATE
