allopurinol Flashcards
1
Q
indication
A
LT control of gout
2
Q
MOA of allopurinol
A
reduces the formation of uric acid crystals
3
Q
type of drug
A
xanthine oxidase inhibitor
4
Q
When to start allopurinol Tx and when NOT to?
A
NOT during an attack
2-3 weeks after attack has settled
5
Q
maintenance dose of allopurinol
A
100-300mg daily
6
Q
s/e with allopurinol
A
rash
- stop if rash develops
- can re-introduce if rash was mild
- discontinue if reoccurs
7
Q
other indicaiton for allopurinol
A
tumour lysis syndrome in chemotherapy
8
Q
allouprinol and renal impairment
A
reudce dose in renal impairment
9
Q
major interaction with allopurinol
A
azathioprine
10
Q
Interaction between allopurinol and azathioprine
A
- AZA is metabolised to 6MP
- 6MP is metabolised by both xanthine oxidase and TPMT
- ALL inhibits xanthine oxidase
- so only TMPT can metabolise AZA (some patients have low/no TMPT)
- can become toxic
