Clotting Factor Pathway And Pathology Flashcards
1
Q
Prothrombin time (PT) reflects
A
Extrinsic pathway
2
Q
APTT reflects
A
Intrinsic pathway
3
Q
Genetics of von villebrand deficiency
A
AD
4
Q
Hemophilia A and B genetics
A
X linked recessive
5
Q
Hemophilia A and B is deficiency of
A
Factor 8 and 9
6
Q
Vitamin K activates which factors
A
2,7,9,10
7
Q
Protein C inactivates which factor
A
Factor 5 and 8
8
Q
Warafarin inhibits vitamin K by?
A
Inhibits epoxide reductase inhibiting formation of reduced vitamin ( active form)
9
Q
How to reverse warfarin
A
Vitamin K
For fast reversal FFP or PCC
10
Q
How does enoxaparin cause anticoagulation
A
Enhances the activity of antithrombin 3 which inhibits 7a, 9a, 10a, 11a and 12a
11
Q
How does protein C get activated
A
Thrombin - thombomodulin complex converts protein C to activated form
