Clotting factor diseases Flashcards
1
Q
VonWillebrand disease definition
A
bleeding disorder caused by defect/deficiency of blood clotting protein von willebrand factor (vWF), which is critical to the initial stages of blood clotting
2
Q
What factor does VonWillebrand stabilize
A
factor VIII
3
Q
Vonwilli lab findings
A
PTT and bleeding time prolonged
4
Q
vonwilli tx
A
Desmopressin (DDAVP), antifibrinolytics, vWF and factor VIII concentrates, FFP ad cryoprecipitate
5
Q
Factor V Leiden definition
A
Fenetic dz that is most common congenital cause of venous thrombosis
6
Q
Factor V Leiden tx
A
Asymptomatic pts do not need anticoagulation
symptomatic: LMWH, warfarin
7
Q
Factor V Leiden dx
A
DNA based test for factor V mutation
