Clotting

Question 1

Which patients are the most recognised to need anti-thrombotic treatment?

Answer 1

IMHA in dogs (mostly pulmonary thromboembolism)
PLN in dogs
Acute pancreatic necrosis, particularly when concurrent
considered for dogs receiving corticosteroids where other risk factors for thrombosis exist
dogs with cancer where hypercoagulability is demonstrated, or where other risk factors for thrombosis exist
dogs with sepsis where hypercoagulability is demonstrated, or where other risk factors for thrombosis exist
when an ischemic stroke is identified and a concurrent medical condition associated with a risk for thrombosis is present
HCM in cats - especially those with LA enlargement, spontaneous echo contrast, and Hx of ATE

Question 2

What are the highest risk patients for thrombosis?

Answer 2

Dogs with IMHA or PLN.

Cats with cardiomyopathy and associated risk factors

Dogs or cats with >1 disease/risk factor for thrombosis (eg, pancreatitis with sepsis).

Question 3

What is preferred for venous thromboembolism treatment?

Answer 3

anticoagulants may be more effective than antiplatelet agents for venous thromboembolism (VTE) prevention in dogs in general and in dirofilariasis specifically

Question 4

What is preferred treatment for arterial thromboembolism?

Answer 4

Anti platelets over anti-coagulants

Question 5

How do you give clopidogrel

Answer 5

Loading dose recommended of 4-10mg/kg

Then 1.2-3mg/kg SID