clotting

Question 0

blood test for intrinsic pathway function

how long does it take (intrinsic to common pathway time)

Answer 0

[activated] partial thromboplastin time 25-36 seconds

Question 1

Test for the common pathway function

how long does it take (fibrinogen to fibrin)

Answer 1

thrombin time 15-18 secs

Question 2

major drug that affects the intrinsic pathway

Answer 2

heparin

Question 3

major extrinsic pathway drug

Answer 3

warfarin/coumadin

Question 4

Test for the extrinsic pathway

How long does it take (extrinsic to common)

Answer 4

Prothrombin Time [PT], normally 13-17 secs

Question 5

What test is often used in place of a PT, where results are independent of reagents and methods used

Answer 5

INR=(pt’s PT)/(mean normal PT)

Question 6

DIC will do what to fibrin degradation products (FDP)

Answer 6

decreased FDP (Disseminated Intravascular Coagulation= excess thrombin)

Question 7

Increases FDP/ D-dimer

Answer 7

inflammation and necrosis

Question 8

How does aspirin affect platelets

Answer 8

clotting function of platelet lost its whole life

Question 9

Sign of IDIOPATHIC ITP

Answer 9

Immune thrombocytopenic Purpura increased megakaryocytes in the marrow

Question 10

thrombocytopenia on CBC but all other clotting tests normal

Answer 10

Thrombotic Thrombocytopenic Purpura

Question 11

condition ACQUIRED through sepsis, pregnancy, or trauma

Answer 11

Disseminated Intravascular Coagulopathy