Clostridium Flashcards
1
Q
Tetani disease
A
Tetanus
2
Q
Botulinum disease
A
Botulism
3
Q
Perfringes disease
A
Gas gangrene & food poisoning
4
Q
Difficile disease
A
Pseudomembranous colitis
5
Q
Tetani toxin
A
Tetanolysin (not a virulence factor)
Tetanospasmin (virulence factor)
6
Q
Tetani action
A
Blocks glycine/GABA release–>spastic paralysis
7
Q
Botulinum toxin
A
Neurotoxins A,B,E,F,H
H is most toxic substance on Earth
8
Q
Botulinum action
A
Blocks acetylcholine release–>flaccid paralysis
9
Q
Botulinum treatment
A
Passive immunization and supportive care
10
Q
Perfringes toxin
A
Numerous
11
Q
Perfringes action
A
Toxin production–>abdominal pain and watery diarrhea
12
Q
Difficile toxin
A
Enterotoxin A
Cytotoxin B
13
Q
Difficile action
A
Kills mucosal surface and then inflames underlying stroma
14
Q
Difficile diagnosis
A
NAAT (PCR) for toxins in stool
