[CLMD] Gout/Pseudogout [Johnston]

Question 1

Uric acid is the end product of?

Answer 1

Purine degradation

Question 2

What is the name of the crystal that forms with gout?

Answer 2

Monosodium urate monohydrate crystals (MS)

Question 3

What are the characteristics of the MS gout crystals?

Answer 3

Needle shape

Negative birefringent

Question 4

Most common joint affected by gout?

Answer 4

1st MTP podagra

Question 5

Characteristics of acute gouty arthritis?

Answer 5

Pain

Erythema

Warmth

Tender

Swollen

Question 6

Characteristics of chronic arthritis?

Answer 6

Tophi

Renal insufficieny

Question 7

MOA of allopurinol/febuxostat?

Answer 7

Xanthine oxidase inhibitors

Question 8

What are three categories of drugs you can use to treat gout?

Answer 8

Steroids

Colchicine

Biologics

Question 9

What is the pathology of pseudogout?

Answer 9

Deposition of calcium pyrophosphate dehydrate

Question 10

What are the microscopy findings in pseudogout?

Answer 10

Weak positive birefringence

Short, blunt rods