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Drug Interactions > Clinically Significant Drug-Drug Interactions > Flashcards

Clinically Significant Drug-Drug Interactions Flashcards

1
Q

Omeprazole

A

Clopidogrel

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2
Q

Clopidogrel

A

Omeprazole

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3
Q

Digoxin

A

Amiodarone (inhibitor, so it increases the concentration of Digoxin in the blood).

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4
Q

Amiodarone

A

Digoxin (substrate)

Amiodarone is an enzyme nhibitor, so it increases the concentration of Digoxin in the blood.

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5
Q

Methotrexate

A

Trimethoprim/ Co-trimoxazole

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6
Q

Trimethoprim

A

Methotrexate

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7
Q

Co-trimoxazole

A

Methotrexate

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8
Q

Clarithromycin

A

Simvastatin (substrate).

Clarithromycin is an enzyme inhibitor, so it increases the concentration of Simvastatin in the blood.

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9
Q

Carbamazepine

A

Clozapine (substrate)

Carbamazepine is an enzyme inducer, so it reduces the concentration of Clozapine in the blood.

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10
Q

Simvastatin

A

Clarithromycin (inhibitor, so it increases the concentration of Warfarin in blood).

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11
Q

Clozapine

A

Carbamazepine (inducer, so it reduces the concentration of Warfarin in blood).

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12
Q

Phenytoin

A

Folic acid

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13
Q

Folic acid

A

Phenytoin

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14
Q

Methotrexate

A

NSAID

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15
Q

NSAID

A

Methotrexate

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16
Q

PARKINSON’S

A

Haloperidol, Metoclopramide, Prochlorperazine

17
Q

St. John’s Wart

A

Warfarin (substrate)
St. John’s Wart is an inducer, so it reduces the concentration of Warfarin in blood.

18
Q

Warfarin

A

St. John’s Wart (inducer, so it reduces the concentration of Warfarin in blood).

Drug Interactions (5 decks)

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