Clinical Research Associate / Research Administrator Flashcards
what important twin studies do you know about specific to psychology
newbauer study
separation of orphaned identical twins and triplets into homes with different economic climates
anything to do with genetic component and ‘risk’ of mental health illness
e.g Sz
9% for 1st degree relative, 27% for children with 2 affected parents and 50% for MZ twins
basic principle that in MZ twins reared in different environments, the % risk of concordance is indicative of the genetic heritability of disorder
- lack of consideration of shared / differences during prenatal environment
what important twin studies do you know about
by twinsuk
ultraprocessed foods
identical twins - same nutritional values food but one UP and one whole food
blood sugar and fat level increased, with headaches and not satiated
PREDICT
no one size fits all for dietary advice as even in MZ twins reaction to food groups and same diet is not the same
- variation in blood responses
- MZ only shared 37% of gut bacteria (strangers is 35%)
what is the general utility of using twins (i.e Mz vs Dz and the science behind it)
monozygotic = identical - 100% same dna genomes and always the same gender - developed from 1 embryo (fertilisation of one egg by one sperm)
- idea is if something is largely influenced by genetics, you would expect to see similar levels / prevalence in MZ twins (& at the same time reveals the extent of environmental influence)
dizygotic (fraternal) = non-identical - developed from 2 separate embryos (fertilisation of 2 eggs by 2 sperms)
genotype & phenotype
geno - combination of alleles possessed for a specific gene - purely from parents
pheno - combination of individuals observable characteritstics and traits - influenced by ^ & environmental, lifestyle and epigenetics (how env influence gene expression) factors
have to consider the equal environments assumption - assuming that extent to which MZ and DZ twins share the same environments is the same - this may not be the case
how will i demonstrate the px always comes first + create a safe and positive experience for them
taking time to listen, read and understand the information provided by participants and their family members both over the phone, email, and in written information.
Should I either be told or get the sense that they are having a more negative experience, or do not feel completely safe, I would urgently flag this to the appropriate team member, as a priority, to demonstrate the patient always comes first.
prev demonstrated in research by flagging data decline to relevant team members and inclusive and safe experience for blind patient in exercise class
what is my understanding of the term ‘good clinical practice’
& what is the general purpose of healthcare research?
agreed international standard for conducting clinical research
GCP in research means you will:
protect the rights and safety of patients taking part in research studies
collect reliable research data
(by the NIHR - national institute for health and care research)
purpose: - through evidence-based solutions
* improving health outcomes
* improving patient wellbeing
* impacting health policies
what are the administrative duties i have undertaken in chief-pd (currrent role)?
large scale data entry
large scale scanning and uploading of documents into correct folders, marking information onto the correct spreadsheets
collection of data from another site
sending out of studies materials
relaying patient queries to the correct staff member
what are the administrative duties i have undertaken in a primary care setting?
use of systmone and outcomes4health (learnt very quickly)
communication to patients, allied health professionals and third party bodies via email, referrals, telephones and post
reporting results, booking appointments, answering queries etc.
some patients were involved in studies so receipt of study documentation
describe the chief-pd trial? what have i learnt about clinical research whilst working there?
cholinersterase inhibitors to prevent falls in parkinsons disease
bristol med school - ageing and movement research group
- with PD, experienced a fall within previous year
largest trial using a novel drug treatment in the uk
600 participants from 39 uk sites
on cholinesterase inhibitors through transdermal patches (typically used for ppl with memory problems)
manage priorities under pressure
admin & booking for covid clinic alongside regular running of gp with reduced staff
what is twins uk?
health study of over 16 000 uk twins
multiple studies at one time
largest uk adults twin registry and most clinically detailed in the world
> 18 y/o