Clinical Research Flashcards
Pros of case studies
unique phenomena (it allows you to look at a rare phenomena); used to generate hypotheses-
Cons of case studies
Internal validity threats (e.g., lack of control- no systematic way to implement your control setting; no comparison group to compare) and external validity threats (e.g., hard to generalize it to the whole population)
Single Case Studies/Design
(A-B), or (ABAB):
Pros of single case
More internal control than case studies (e.g., standardized measure; systematic way you can ) and operationalized variables- defining what your variables are
Cons of single case
External validity threats (e.g., ); is removing a treatment ethical?
Correlational Designs
bc you’re not introducing any controls- it has the most vulnerability towards internal validity
Pros of correlational designs
Good external validity; descriptive; and generate hypothesis based on conceptual relationships
Cons of correlational designs
Internal validity threats (e.g., no random assignment or manipulation) and no causality
Pros of Experimental Design
random assignment!!!!!!!!!!
manipulation or control of variables
Cons of Experimental design
external validity threats (e.g., )
Threats to internal validity:
- history
- repeated testing-
- statistical regression
- selection bias
Threats to external validity
- sample characteristics
- stimulus characteristics
- reactivity
Sample characteristics
characteristics of research participants do not maponto population
E.g. ACT + ERP study with only PSYC 101 students (e.g., convenient sample- they are not going to reflect typical population with anxiety disorder, or OCD)
Stimulus characteristics
features of the study constrain generalizability:
E.g., highly trained therapists in RCT (often have clinicians- they are trained very well but in the real world, that is not the case because it is not implemented as well as highly trained therapists in RCT)
Reactivity
different response because know they are in a study/assessment
E.g., participants always complete H.W. for a DBT study
Statistical significance
difference scores (pre/post) on a measure are larger than chance; the difference between two groups’ scores on a measure is greater than chance
<5% chance the difference score would occur due to random error (e.g., internal/external validity threats)
Clinical significance
Did the intervention have a meaningful impact on function?
True/False: if something is statistically significant, it also means that it is clinically significant.
F