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M R C P > clinical pharmacology and toxicology > Flashcards

clinical pharmacology and toxicology Flashcards

1
Q

when to monitor phenytoin drug levels

A

immediately beforelast dose

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2
Q

insecticide poisoning ecg

A

bradycardia

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3
Q

erythromycin use in gastroparesis

A

promotes gastric emptying- prokinetic

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4
Q

pneumonic for p450 inducers

A

BS CRAP GPS induces rage!!

Barbituates
St johns wort

Carbamazepine
Rifampicin
Alcohol
Phenytoin

Grisefulvin
Phenobarbital
Sulphonylureas

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5
Q

liver transplant post paracetamol overdose MAIN criteria

A

pH <7.3

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6
Q

which abx lowers seizure threshold

A

ciprofloxacin

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7
Q

metformin can cause which vitamin def

A

b12

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8
Q

most useful prognostic marker in paracetamol overose

A

prothrombin time

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9
Q

myriad ECG changes, hypotension, metabolic acidosis, hypoglycaemia and classically tinnitus, flushing and visual disturbances. Flash pulmonary oedema may occur

A

quinine toxocity

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10
Q

corneal opacities

A

amiodarone

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11
Q

rapid sequence induction

A

suxam

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12
Q

teicoplanin moa

A

inhib cell wall growth

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13
Q

drugs worsen lithium toxicity

A

MANT

Metronidazole
ACEi
NSAIDs
Thiazides (top)

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14
Q

ocreotide =?

A

somatostatin analogue

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15
Q

activation of the AMP-activated protein kinase (AMPK)
diabetic med

A

metformin

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16
Q

Inhibitors of the P450 system include

A

antibiotics: ciprofloxacin, erythromycin
isoniazid
cimetidine,omeprazole
amiodarone
allopurinol
imidazoles: ketoconazole, fluconazole
SSRIs: fluoxetine, sertraline
ritonavir
sodium valproate
acute alcohol intake
quinupristin

17
Q

adrenaline dose Recommend Adult Life Support (ALS) adrenaline doses
anaphylaxis and cardiac arrest

A

anaphylaxis: 0.5ml 1:1,000 IM
cardiac arrest: 10ml 1:10,000 IV or 1ml of 1:1000 IV

18
Q

how does levothyroxine act

A

Levothyroxine acts via nuclear receptors

19
Q

which TB med causes gout

A

pyrazinamide

20
Q

most medications are first order kinetics

which drugs and acronym are zero order

A

Police (phenytoin)
Stop (salicylate)
Heavy (heparin)
Drinkers (ethanol)

20
Q

most medications are first order kinetics

which drugs and acronym are zero order

A

Police (phenytoin)
Stop (salicylate)
Heavy (heparin)
Drinkers (ethanol)

21
Q

what is amiloride and MOA

A

potassium sparing diuretic
MOA= epithelial sodium channel

22
Q

Antidote anti freeze
what is the toxic agent in antifreeze1

A

anti freeze toxic agent= ethylene gylcol

Antidote = fomepizole
competitive inhibitor of alcohol dehydrogenase

23
Q

FLEICANIDE MOA

A

Flecainide blocks the Nav1.5 sodium channels in the heart

24
Q

MM linked with pyoderma gangrenosum

A
25
Q

Ciclosporin + tacrolimus: mOA

A

inhibit calcineurin thus decreasing IL-2

26
Q

Dobutamine is an example of:
mOA

A

BETA 1 agonist

27
Q

Denosumab MOA

A

RANKL inhibitor= prevents osteoclast development

28
Q

bitter smell, burnt plastics,,=== what poisoning
and what does it cause on a molecular level

A

CYANIDE POISONING
Inhibition of cytochrome c oxidase

29
Q

inappropriately stored seafood toxin causing anaphylaxis

A

scromboid

M R C P (18 decks)

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