clinical pharmacology and toxicology Flashcards
when to monitor phenytoin drug levels
immediately beforelast dose
insecticide poisoning ecg
bradycardia
erythromycin use in gastroparesis
promotes gastric emptying- prokinetic
pneumonic for p450 inducers
BS CRAP GPS induces rage!!
Barbituates
St johns wort
Carbamazepine
Rifampicin
Alcohol
Phenytoin
Grisefulvin
Phenobarbital
Sulphonylureas
liver transplant post paracetamol overdose MAIN criteria
pH <7.3
which abx lowers seizure threshold
ciprofloxacin
metformin can cause which vitamin def
b12
most useful prognostic marker in paracetamol overose
prothrombin time
myriad ECG changes, hypotension, metabolic acidosis, hypoglycaemia and classically tinnitus, flushing and visual disturbances. Flash pulmonary oedema may occur
quinine toxocity
corneal opacities
amiodarone
rapid sequence induction
suxam
teicoplanin moa
inhib cell wall growth
drugs worsen lithium toxicity
MANT
Metronidazole
ACEi
NSAIDs
Thiazides (top)
ocreotide =?
somatostatin analogue
activation of the AMP-activated protein kinase (AMPK)
diabetic med
metformin
Inhibitors of the P450 system include
antibiotics: ciprofloxacin, erythromycin
isoniazid
cimetidine,omeprazole
amiodarone
allopurinol
imidazoles: ketoconazole, fluconazole
SSRIs: fluoxetine, sertraline
ritonavir
sodium valproate
acute alcohol intake
quinupristin
adrenaline dose Recommend Adult Life Support (ALS) adrenaline doses
anaphylaxis and cardiac arrest
anaphylaxis: 0.5ml 1:1,000 IM
cardiac arrest: 10ml 1:10,000 IV or 1ml of 1:1000 IV
how does levothyroxine act
Levothyroxine acts via nuclear receptors
which TB med causes gout
pyrazinamide
most medications are first order kinetics
which drugs and acronym are zero order
Police (phenytoin)
Stop (salicylate)
Heavy (heparin)
Drinkers (ethanol)
most medications are first order kinetics
which drugs and acronym are zero order
Police (phenytoin)
Stop (salicylate)
Heavy (heparin)
Drinkers (ethanol)
what is amiloride and MOA
potassium sparing diuretic
MOA= epithelial sodium channel
Antidote anti freeze
what is the toxic agent in antifreeze1
anti freeze toxic agent= ethylene gylcol
Antidote = fomepizole
competitive inhibitor of alcohol dehydrogenase
FLEICANIDE MOA
Flecainide blocks the Nav1.5 sodium channels in the heart
MM linked with pyoderma gangrenosum
Ciclosporin + tacrolimus: mOA
inhibit calcineurin thus decreasing IL-2
Dobutamine is an example of:
mOA
BETA 1 agonist
Denosumab MOA
RANKL inhibitor= prevents osteoclast development
bitter smell, burnt plastics,,=== what poisoning
and what does it cause on a molecular level
CYANIDE POISONING
Inhibition of cytochrome c oxidase
inappropriately stored seafood toxin causing anaphylaxis
scromboid
