Clinical Pharmacology and Antibiotic Use Flashcards
Aminoglycosides Toxicity/Adverse Effects
- Nephrotoxic + Ototoxic (deafness)
- AVOID (last resort drug)
Cephalosporins + Penicillins Toxicity/Adverse Effects
- Immune-Mediated Diseases (IMHA, or IBD)
Doxycycline Toxicity/Adverse Effects
- Esophageal Stricture in Cats
Tetracyclines Toxicity/Adverse Effects
- Renal Tubular Disease + Tooth Enamel Erosion(Puppies < 6 months = yellow teeth)
Sulfonamides Toxicity/Adverse Effects
- KCS (dry eye)
- Blood Dyscrasia + Polyarthritis (black/tan dogs = Dobermans)
Enrofloxacin Toxicity/Adverse Effects
- NO CATS (Blindness)
- Failure of Cartilage Development in Young Animals (large breed dogs)
- +/- Seizures
Chloramphenicol Toxicity/Adverse Effects
- Aplastic Anemia in Humans
- OWNER COMPLIANCE is ESSENTIAL (GLOVES)
Metronidazole
CNS
Treatment of Staph Pyoderma
- Cephalosporin
Treatment of Abscesses
Commonly caused by Anaerobes
- Clindamycin (Anaerobic!)
- Clavamox
- Cephalosporins
Treatment of Nocardia
- High dose penicillins + Potentiated Sulfa
Treatment of Bacterial Pneumonia
Combination Therapy
- Ampicillin (high dose) + Enrofloxacin (Cats use Marbofloxacin)
OR
- Ticarcillin/Clavulanate
Treatment of Pyothorax
- Penicillins
+/- Potentiated Sulfa (If Nocardia)
+/- Metronidazole
Treatment of Upper Respiratory Disease
- Clavamox
- Clindamycin
Treatment of Cholangiohepatitis
- Clavamox
+/- Metronidazole