Clinical Pharmacology

Question 1

Gingival hyperplasia cause?

Answer 1

Amlodipine

Question 2

Diuretic that can cause photosensitivity?

Answer 2

Thiazides

Question 3

Drugs causing photosensitivity

Answer 3

thiazides
tetracyclines, sulphonamides, ciprofloxacin
amiodarone
NSAIDs e.g. piroxicam
psoralens
sulphonylureas

Question 4

Ciclosporin side-effects

Answer 4

everything is increased - fluid, BP, K+, hair, gums, glucose

Question 5

Ethylene glycol toxicity

Answer 5

Features of toxicity are divided into 3 stages:
Stage 1: symptoms similar to alcohol intoxication: confusion, slurred speech, dizziness
Stage 2: metabolic acidosis with high anion gap and high osmolar gap. Also tachycardia, hypertension
Stage 3: acute kidney injury

Question 6

N-acetylcysteine mechanism in paracetamol overdose

Answer 6

Replenishes glutathione

Question 7

Heparin-induced thrombocytopaenia

Answer 7

antibodies form against complexes of platelet factor 4 (PF4) and heparin