Clinical Pharmacokinetics I Flashcards
Drug Concentration =
Mass/Volume
1 L = ______ mL
1,000
Cp=
Plasma Concentration
Cb=
Blood Concentration
What is blood serum?
Plasma minus clotting proteins
Plasma, Serum, or Blood.
Which tends to be used in pharmakinetics?
Plasma, but it depends on the assay
Cu=
Band concentration
Css
Steady State Concentration
What is ADME?
Is it for PK or PD?
Absorption, Distribution, Metabolism, Elimination
PL
What is the fundamental hypothesis for pharmacokinetics?
There is a predictable relationship between plasma/serum concentration of a drug and its effect
What is absorption?
The process of a drug entering the systemic circulation
What is distrubition assessing?
The dispersion of a drug throghout fluids and tissues of the body
ex. vascular space –> extravascular space
What is metabolism (biotransformation) assessing?
Irreversible transformation of parent compounds into daughter compounds
List four organs responsible for drug metabolism
Liver, Kidney, Gut, Skin
What is Elimination assessing?
The removal of the drug from the body
If the circulatory system is considered comparative to a one compartment system, what equation can be used to determine the concentration of drug?
C=m/V
What is AUC?
Area Under the CT plot curve in a single dose interval
What does the AUC tell you about
The behavior of the drug moving through the body
The therapautic window exists between…
Minimum Toxic Concentration and Min Effective Concentration
Biggest variable influencing drug absorption?
Route of Administration
What is bioavailability (F)?
The fraction (%) of the amount of drug entering the systemic circulatory system
Bioavailability of a IV distributed drug?
1
Equation for F
(Amount of Drug Absorbed into systemic)/(Amount administered)
