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Pharmacology -- Test #1 > Clinical Pharmacokinetics I > Flashcards

Clinical Pharmacokinetics I Flashcards

1
Q

Drug Concentration =

A

Mass/Volume

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2
Q

1 L = ______ mL

A

1,000

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3
Q

Cp=

A

Plasma Concentration

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4
Q

Cb=

A

Blood Concentration

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5
Q

What is blood serum?

A

Plasma minus clotting proteins

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6
Q

Plasma, Serum, or Blood.

Which tends to be used in pharmakinetics?

A

Plasma, but it depends on the assay

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7
Q

Cu=

A

Band concentration

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8
Q

Css

A

Steady State Concentration

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9
Q

What is ADME?

Is it for PK or PD?

A

Absorption, Distribution, Metabolism, Elimination

PL

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10
Q

What is the fundamental hypothesis for pharmacokinetics?

A

There is a predictable relationship between plasma/serum concentration of a drug and its effect

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11
Q

What is absorption?

A

The process of a drug entering the systemic circulation

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12
Q

What is distrubition assessing?

A

The dispersion of a drug throghout fluids and tissues of the body
ex. vascular space –> extravascular space

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13
Q

What is metabolism (biotransformation) assessing?

A

Irreversible transformation of parent compounds into daughter compounds

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14
Q

List four organs responsible for drug metabolism

A

Liver, Kidney, Gut, Skin

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15
Q

What is Elimination assessing?

A

The removal of the drug from the body

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16
Q

If the circulatory system is considered comparative to a one compartment system, what equation can be used to determine the concentration of drug?

A

C=m/V

17
Q

What is AUC?

A

Area Under the CT plot curve in a single dose interval

18
Q

What does the AUC tell you about

A

The behavior of the drug moving through the body

19
Q

The therapautic window exists between…

A

Minimum Toxic Concentration and Min Effective Concentration

20
Q

Biggest variable influencing drug absorption?

A

Route of Administration

21
Q

What is bioavailability (F)?

A

The fraction (%) of the amount of drug entering the systemic circulatory system

22
Q

Bioavailability of a IV distributed drug?

A

1

23
Q

Equation for F

A

(Amount of Drug Absorbed into systemic)/(Amount administered)

Pharmacology -- Test #1 (8 decks)

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