Random Shit I Forgot About when I made cards before

Question 1

Identify Familial Defect in Q10 synthesis

Answer 1

Leigh’s encephalomyopathy

Question 2

What is melatonin (chemically)

Answer 2

5 methoxy-N-acetyl tryptamine

Question 3

Difference between EC50, Kd, LD50

Answer 3

EC50 – Concentration at which a drug is 50% effective
Kd – Concentration at which half the receptors are bound to drug
LD50 – Concentration at which a drug is 50% lethal

Question 4

The tachyphylaxis example discussed which two drugs

Answer 4

Repeated ephedrine followed by epinephrine

Question 5

How does elimination decrease lipid solubility and increase water solubility?

Answer 5

Increases the polarity of drug molecules

Question 6

Given example of a pro-drug

Answer 6

Tamoxifen–>4-hydroxytamoxifen

Question 7

Given example of toxification

Answer 7

Benzopyrene (in smokers)

Question 8

kinda big deal inhibitor of cyps…

Answer 8

ketoconazole

Question 9

In the Induction graph, who is the most powerful inhibitor of CYPS?

Answer 9

ketoconazole

Question 10

In the Induction graph, who is the less powerful inhibitor of CYPS?

Answer 10

Grapefruit Juice

Question 11

In the Induction graph, who is the inducer of CYPs?

Answer 11

Rifampin

Question 12

Why is ritonavir given with lopinavir?

Answer 12

Ritonavir inhibits CYP3A4, so Lop. will have in increase in its bioavailability

Question 13

Descriptors of CYP2C9

Answer 13

Neutral/Acidic
Amphipathic
Hydrophobic region near oxidation

Question 14

Name two CYP inducers

Answer 14

Rifampin

Dexamethasone

Question 15

CYP3A4 is inhibited by…

Answer 15

HIV antivirals, TB treatments, and clarithromycin

Question 16

How does Liu distinguish PD and PK

Answer 16

PK: how the drug concentration changes as it moves through compartments in your body

PD: How the drug exerts its effect on your body