Clinical Neuroscience Flashcards
1
Q
What are the components of the BBB?
A
- endothelial cells with tight junctions
- astrocyte foot processes
- basement membrane
2
Q
Which structures lack a BBB?
A
- area postrema
- median eminence of the hypothalamus
- neurohypophysis
3
Q
What is Dales principle?
A
A given neuron only releases one type of NT and its effect on the post-synaptic terminal is the same across all connections (acetylcholine released and causes excitation to all terminal neurons that have connections)
4
Q
How is acetylcholine synthesized?
A
acetyl coenzyme A + choline –> acetylcholine by choline acetyltransferase
5
Q
How is glutamate synthesized?
A
transamination of alpha-ketoglutarate
glutamine to glutamate by enzyme glutaminase
6
Q
how is GABA synthesized?
A
synthesized from glutamate via enzyme glutamic acid decarboxylase (GAD)
