Clinical chem must to know Flashcards by Jena Sy

It is the daily monitoring of accuracy and precision

Internal QC

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QC that has long-term accuracy

External QC

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How long is the minimum availability for QC materials?

Minimum of 1 year

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It is the dispersion of values from the mean

Standard Deviation

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Relative magnitude of variability (%)

Coefficient of Variance

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SD^2 and measure of variability

Variance

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Means of 2 groups of data

T-test

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SD of 2 groups of data

F-test

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V mask and earliest identification of Trend

CUSUM Graph

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Compare results from diff. lab

Youden/Twin plot

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Graph for acceptable limits of variation

Shewhart Levey-Jennings Chart

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Gradual loss of reliability

Trend

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Cause of Trend

Deterioration of reagents (Systematic error)

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Cause of Shift

Improper calibration (Systematic error)

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One side or either side of mean

Shift

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Degree of flatness or sharpness

Kurtosis

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Precision is what type of error?

Random error

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Accuracy is what type of error?

Systematic error

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Distance between successive peaks (nm)

Wavelength

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Measures light intensity in a narrower wavelength

Spectrophotometric Measurement

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Measures light intensity w/o consideration of wavelength

Photometric Measurement

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Lamps that has UV light

Deuterium lamp
Mercury Arc
Xenon Lamp
Hydrogen lamp

IR (Infrared light)

Merst glower

Globar (Silicone carbide)

Most common cause of linearity

Stray light

Most commonly used monochromator

Diffraction gratings

Prevents stray light

Nickel sulfate

Anti-stray light

Cutoff filter

Most commonly used cuvet

Alumina silica glass cuvet

Simplest detector for filter photometers

Barrier layer cell/ photocell/ photovoltaic cell

Most common type of tube in analytical chem

Photomultiplier tube

Most common type of tube

Photomultiplier tube

Formula of Absorbance

A = 2-log%T

Measure light absorbed by atoms dissociated by heat

Atomic Absorption Spectroscopy

Molecules migrate through a pH gradient

Isoelectric focusing

It detects DNA

Southern blot

It detects RNA

Northern blot

It detects proteins

Western blot

It is used as screening test for drugs

Thin Layer Chromatography

Gold standard for drug testing

Gas Chromatography/Mass Spectrometry (GS/MS)

Major disadvantage of Fluorometry

Quenching

6x stronger than Borosilicate

Corex (corning)

Can be heated for 900C

Vycor (corning)

It has etched rings on top of pipet

Blowout

A transfer pipet for non-viscous fluid; self-draining

Volumetric

A transfer pipet for viscous fluid; w/ etched ring

Ostwald folin

A transfer pipet w/o consideration of a specific volume

Pasteur

w/ graduations to the tip (blowout)

Serological

w/o graduations to the tip (self-draining)

Mohr

TC pipets: (does not disperse exact volume)

Salih-Hellige pipet Lang-levy pipet RBC and WBC pipet Kirk and Overflow pipet

Cleaning solution for glasswares

Acid Dichromate ( H2SO4 + K2Cr2O4 )

Examples of centrifugal analyzer

"RICC" RotoChem IL Monarch Cobas-Bio (Roche) CentrifiChem