Clinical Case - Sheet1-2

Question 1

What to lab results suggest inflammation due to infection?

Answer 1

High WBC and elevated ESR.

Question 2

Neisseria gonorrhoeae

Answer 2

Gram negative. Obligate human pathogen. Diplococci. Oxidase +. Only glucose oxidizer. Virulance factors: specialized pili (allows attachment to mucosal surfaces, prevents phagocytosis), endotoxin (duh! Gram –), IgA protease, capsule.

Question 3

How to treat Neisseria gonorrhoeae?

Answer 3

ceftriaxone (+ doxycycline for concurrent Chlamydia infection).

Question 4

What growth media would you use to isolate Neisseria bacteria?

Answer 4

Thayer-Martin Media (selective media with antibiotics)

Question 5

Clinical presentation of Neisseria gonorrhoeae?

Answer 5

local infection (genital or anorectal), systemic infection (septic arthritis), Complications = sequelae