Clinical - Anorexia Flashcards
What are the two types of AN?
-Restricting type : person restricts food intake on their own
-Binge eating/ Purging type: person self-induces vomiting or misuses laxatives
What are the symptoms of Anorexia?
-Significantly low body weight
-Intense fear of gaining weight
-Body dysmorphia (disturbance in the way ones body weight/shape is experienced)
Symptoms of partial remission?
-After the full criteria for AN was met, Criteria A hasn’t been met for a sustained period but Criteria B or C is still met
Symptoms of full remission?
-After full criteria for AN were previously met, none of the criteria have been met for a sustained period of time
Features of AN?
- Onset
Starts in teenage years
Affects 1:150 15 yr old girls and 1:1000 15 yr old boys - Course
50% fully recover after an episode
30% follow an episodic pattern of weight gain and relapse
20% never fully recover and need hospitalisation - Incidence
In 2007, 1.9% of women and 0.2% of men experience AN in any year
Usually the condition lasts for 6 years
How does Epinephrine explain AN?
(Biological explanation of AN)
-Causes increase in blood pressure, HR and blood sugar levels
-Decreased levels of epinephrine have been associated with AN
How does Norepinephrine explain AN?
(Biological explanation of AN)
-Involved in body image and the way a person sees themselves
-Excess norepinephrine in the ventromedial hypothalamus causes a person to stop eating
How does Serotonin explain AN?
(Biological explanation of AN)
-Has a well confirmed role in regulation of eating behaviour
-Excess serotonin in the ventromedial hypothalamus causes a person to stop eating.
-This is because it leads to a high level of anxiety, leading to binging/purging behaviours.
-Can also lead to high levels of fear of gaining weight
-Over time serotonin levels can appear low due to malnutrition from not eating
-Barbarich (2002) reports that high levels of serotonin in AN and OCD shows they may both be causes by serotonin dysfunction therefore explaining some of the perfectionist and compulsive behaviour seen in anorexics.
How does Dopamine explain AN?
(Biological explanation of AN)
-Involved in reward pathway
-Over activity in dopamine receptors of the basal ganglia is linked to difficulty in associating food with the pleasurable feeling
-Dopamine over activity also seems to increase anxiety in anorexics instead of a pleasure response
Strength of neurotransmitter explanation (Serotonin)
(Biological explanation of AN)
-Research evidence for the role of serotonin
-Bailer et al found significantly higher serotonin activity in the women recovering from the purging type of AN compared to healthy controls.
-Highest levels of serotonin activity in women who showed the most anxiety, suggesting persistent disruption of serotonin levels leads to increased anxiety, triggering AN
Strength of neurotransmitter explanation (Dopamine)
(Biological explanation of AN)
-Kaye et al compared dopamine activity of 10 women recovering from AN and 12 healthy women.
-In the ANs they found over activity in dopamine receptors in the basal ganglia and reward centres where dopamine affects the interpretation of harm and pleasure.
-Therefore this shows that dopamine is linked to anorexia
Weakness of neurotransmitter explanation
(Biological explanation of AN)
-There are issues with research methods used to investigate biological explanations for anorexia such as Co-morbidities
-We don’t know what the exact cause of behaviour is, it may be one of the other MH issues
APFC of Contemporary Study (Guardia)
Aim - To continue research to see if patients with AN found it difficult to gauge their own body size and if they’d be able to fit through a door frame.
Procedure - 25 female patients, 24 yrs old, who met DSM criteria for AN
(12 restrictive type, 13 binge/purge type)
-25 healthy female controls who were all students
-51 Door frame shape projected onto a wall varying from 30-80cm wide
-Projected in a random order and each frame was presented 4 times and asked if they could fit through
-Then asked if a female researcher in the room could fit through
Findings - AN patients showed a significant overestimation of body size in themselves
-Much more accurate in predicting the body size of the other person in relation to their ability to pass through the frame.
-Patients that lost weight in the last 6 months showed a greater difference between their own and the other person passability perceptions
Conclusion - The brain still perceives the body to be a larger size despite visual information contradicting this
-Patients with AN continue to strive to lose weight as their brain doesn’t perceive their current size accurately
AO3 of contemporary study (Guardia)
S - Matched groups on age and education level. This ensures individual differences are ruled out.
S - Previous research by Guardia found that AN didn’t think they could pass through an opening that was clearly wide enough
-Schneider et al also found that people with AN misjudge their own body size, overestimating their body parts by about 30%
W - Researchers suggested that there were significant differences between the control group and the anorexia group, their shoulder width and BMI
-However the weight and size of the experimenters body matched those in the control group much more than those in the AN group
W - Making a visual judgement of a persons ability to pass through a virtual door frame is different to actually attempting to walk through the projected shape.
-Therefore a better methodology may have been to have a participant approach the opening to see if they walk as if thy can fit or if they begin to turn or slow down as if they will not fit.
Biological Treatment for Anorexia - Antipsychotics
-Olanzapine
-Treats schizophrenia also
-Olanzapine blocks DS/D3 receptors on post-synaptic receptors, stopping dopamine from being absorbed
-Blocks 5-HT2A receptors for serotonin in neural pathways in the brain
-Alters motivation and reward perception, reducing obsessive thoughts about food in those with AN
-Weight gain is a side effect a it increases hunger hormone (ghrelin)
-Molina et al (2003) found that patients who took olanzapine reported lower levels of anxiety and less difficulty with eating
Biological treatment for Anorexia -Antidepressants
-Selective Serotonin Reuptake Inhibitors (SSRI’s)
-e.g Fluoxetine
-Block the reuptake of serotonin in pre-synaptic neuron causing levels of the neurotransmitter to increase in the synapse, so more serotonin is passed to the post synaptic neuron.
-Beneficial in maintenance of appetite
-AN patients are less likely to drop out of psychological therapy
Strengths of drug treatment for AN
-There is supporting evidence which demonstrates its effectiveness
-Jensen and Mejlhede (2000) found case studies of 3 patients who had taken Olanzapine.
-The patients showed an increase in positive body image which was also more realistic of what they actually looked like.
-Therefore it seems that drug treatment can be an effective therapy for treating anorexia, and should be considered as a course of treatment perhaps alongside psychological therapies.
HOWEVER
-Small sample sizes are used in these trials, for example 3 patients in this case so this may lead to questions about the reliability of the data since evidence from small scale research is difficult to replicate.
-Therefore it is difficult to make strong conclusions about the effectiveness of drug treatment
-
Weakness of drug treatment for AN
-Not all research suggests drug treatment is effective at treating the disorder
-Ferguson et al (1999) found there was no significant difference between patients given SSRIs compared to those patients on the ward who weren’t given SSRIs in relation to body weight or anxiety.
-Therefore the role of drugs in treating anorexia appears limited
-Drugs are focusing on the symptoms rather than the causes of AN.
-So even if they are successful, it is a merely temporary reduction in symptoms that would be revered if the person stopped taking the drug.
Non-Biological Explanation of AN - Socio-cultural Theory
-Social Factors = SLT (Attention, Retention, Reproduction, Motivation)
-SLT suggests we may learn our eating behaviours through observation of others in our household for example
-Cultural Factors:
-AN is more likely to occur in dance or modelling students compared to other female university students because these groups value the ‘slim body image’ as part of their image as ‘dancers’ and ‘models’ as it’s more normal (Garner & Garfinkel 1980)
-Schwartz et al(1982) conducted a review of Miss America beauty pageant competitors and found that over a 20 year period, the average weight of contestants decreased but the actual average of US females was slightly increasing
A03 of non-biological explanations of AN
STRENGTH
-Support for the idea of a socio-cultural explanation of AN comes from the increase in diagnoses in 1950s
-This increase in diagnoses links with the change towards slimmer models and the preoccupation with body image and dieting in the media
-Furthermore, an increase in males with AN has coincided with changes in ‘men’s magazines’ to include more diet, fitness and body image articles
WEAKNESS
-Cultural explanations might combine with other factors such as a perfectionist personality
-Other factors must make some people more vulnerable to images compared to others
-Evidence shows patients with AN score highly on measures of ‘perfectionism’ - a trait associated with serious concern over making mistakes
STRENGTH
-Support for socio cultural explanation for AN comes from research. Becker (2002) found that in Fiji before TV, girls were unlikely to be concerned about diet or slimming but after TV was introduced, evidence shows they were concerned about body weight and image
-0% said they self-induced vomiting to control weight in 1995 compared to 11.3% in 1998
WEAKNESS
-However, there is good evidence to suggest that biological approaches may be a better explanation of AN (neurotransmitters)
-Therefore, considering both biological and social explanations are well evidenced, perhaps it is possible that some individuals are biologically predisposed to AN but that social conditions influence the development of the disorder.
Non- Biological treatment for AN - CBT
-CBT stands for Cognitive Behavioural Therapy
-(Enhanced CBT = CBT-E)
-Conducted on a 1-2-1 basis between the patient and the therapist
Stage 1:
-Focuses on patients eating behaviour
-Patient is weighed on a weekly basis and regular eating is encouraged
-Patient given information about AN
Stage 2:
-Progress update from stage 1
-Therapist may look into why progress isn’t being made in some instances
Stage 3:
-Main treatment phase consisting of 8-10 weekly sessions
-Directly address potential triggers
Stage 4:
-Patient draws up an agreed plan about how to prevent relapse and manage eating behaviour
-Post-treatment review 5-6 months after to see how the patient has progressed
A03 for non-biological treatment for AN - CBT
STRENGTH:
-Flexibility of treatment
-CBT-E stages can be adapted to meet the requirements of the patient
-Different types of AN and the treatment programme can be tailored to each type
-Advantage as it means the treatment programme can be generated and adapted according to each individual’s circumstances
HOWEVER:
-Requires motivation and so won’t be effective for everyone
-the therapist has to recognise the signs that the patient is not yet ready
STRENGTH:
-Research support for use of CBT-E in treating AN
-Pike et al found the relapse rate for AN patients receiving outpatient CBT was lower (22%) than those receiving nutritional counselling (33%)
-Therefore this treatment is effective for AN
HOWEVER:
-Doesn’t work with comorbid disorders e.g. those with low self-esteem or perfectionist personalities
-Drug treatment may be better if the client isn’t willing to engage in the therapy from the beginning or motivated to change their eating habits
-Perhaps both drug and CBT should be used to provide the most effective treatment for AN patients
Clinical Key Question - A01
(What are the implications for society if anorexia is a learned disorder?)
-Why it’s an issue for society?
-Cost of treatment and effect on the NHS
-Mortality rate of those admitted to hospital is over 10% due to starvation or suicide
-AO1:
-AN could be caused by images and cultural expectations
-Models used to advertise clothing to specific beauty such as ‘size-zero’ models
-90% of cases are females between 13-18yrs
-20% of patients have one episode and recover while 60% follow an episodic pattern of weight gain and relapse over a number of years
Clinical Key Question - A02
(What are the implications for society if anorexia is a learned disorder?)
-OPERANT CONDITIONING
-Positive Reinforcement : Peer acceptance is particularly important during adolescence. As such teens may be more encouraged by praise given by others when they lose weight or stay slim
-Positive Punishment: Whereas teasing and bullying may have an effect on behaviour. Those who do not fit an idealised image may be made fun of for their weight
-The Use of Social Media: Fewer likes and interactions on social media after weight gain (negative punishment)
-SOCIAL LEARNING THEORY
-If they witness a role model that has AN not eat or have a very strict diet etc, they’ll remember and attempt to copy their role model, Eventually, after seeing their role model get praise for being super skinny etc, they’re more likely to do the same