Cliclo de Krebs Flashcards

1
Q

Ruta que genera mucho________para la cadena oxidativa.

A

PODER REDUCTOR.

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2
Q

Producto de la vía

A

10 NADH

2 FADH

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3
Q

Es una ruta_________

A

ANFIBOLICA

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4
Q

De las ____ reacciones totales____ son deshidrogensas

A

8

4

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5
Q

Lugar

A

Matriz mitocondrial

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6
Q

El_______se oxida a Acetil CoA, mediante la__________.

A

Piruvato.

Piruvato deshidrogensa.

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7
Q

No es parte del ciclo, sólo se integra.

NO sucede en eritrocitos.

A

Acetil CoA

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8
Q

Total ATP producidos indirectamente

A

30-32 por molécula de glucosa.

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9
Q

Enzima que cataliza una fosforilación a nivel de sustrato

A

Succinil-CoA sintetasa

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10
Q

Aquellas que sustituyen o proporcionan intermediarios del ciclo de Krebs

A

Anapleróticas

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11
Q

Las siguientes son enzimas ____________

Piruvato carboxilasa
PEP carboxilasa
Enzima málica

A

Anapleróticas

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12
Q

única enzima que se encuentra en la membrana interna mitocondrial en la vía

A

Succinato deshidrogenasa

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13
Q

¿Qué reacción es?

Piruvato + CoA-SH + NAD+ → Acetil-CoA + CO2 + NADH

A

Piruvato a Acetil CoA

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14
Q

Complejos para la convertir piruvato a Acetil CoA

A

(E1) Piruvato deshidrogenasa: utiliza TPP
(E2) Dihidrolipoil transacetilasa: utiliza lipoamida
(E3) Dihidrolipoil deshidrogenasa: utiliza FAD

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15
Q

El ΔG°` es de -33.4 Kj/mol
Reacción espontánea e irriversible.

(Delta G super negativo)

A

Complejo piruvato deshidrogenasa

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16
Q

Ecuación general

A

Acetil-CoA + 3 NAD+ + FAD + Pi + GDP + 2H2O → 3CO2 + 3NADH + 3H+ + FADH2 + GTP
+ CoA

17
Q

Reacciones que producen poder reductor

A

Isocitrato deshidrogenasa (isocitrato → alfa-cetoglutarato)

Complejo alfa-cetoglutarato deshidrogenasa (alfa-cetoglutarato →succinil-CoA)
Succinato deshidrogenasa (succinato → fumarato)
Malato deshidrogenasa (malato → oxaloacetato)
18
Q

No participa directamente en la vía

A

Complejo piruvato deshidrogenasa.

19
Q

Regulan la vía

A
  1. Citrato sintasa
  2. Complejo enzimatico alfa cetoglutarato deshidrogenasa
  3. Isocitrato deshidrogenasa