Cleft Lip and Palate (Redford) Flashcards
What is the most common craniofacial anomaly requiring complex orthodontic intervention(?
Cleft lip and palate
Cleft lip and palate is most common in what racial demographic?
Native Americans
What is the order of prevelance racially for cleft lip and palate (CLP) occurrence?
- Native Americans (most)
- Asians (2nd)
- Caucasians (3rd)
- African-Americans (4th)
What is the rate of occurrence of CLP in Native Americans?
1:280
What is the rate of occurrence of CLP in Asians?
1:425
What is the rate of occurrence of CLP in Caucasians?
1:700
What is the rate of occurrence of CLP in African-Americans?
1:1700
What gender is more prone to CLP?
Males
If CLP is unilateral, it more commonly occurs on which sid?
Left
If CLP is bilateral, on which side is it more severe?
Left
What is the most significant etiology for clefts (found in 20-30% of patients with CLP)?
Heredity
What are 4 possible teratogens linked to CLP?
- Steroids
- Amphetamines
- Anticonvulsants
- Alcohol (Fetal Alcohold Syndrome)
What are 2 environmental factors linked to CLP?
- Radiation
2. Hypoxia
If a parent has a child with a cleft, what is the percent risk subsequent children will also have a cleft?
2-4%
If more than one child in a family has a cleft, what is the risk that those siblings, when they have children, will have children with clefts?
5-6%
What gender child increases their siblings’ risk for having children with clefts?
If the sibling with a cleft is female
Increased age of which: (maternal or paternal?) age is associated with increased frisk for cleft?
Increased paternal age
What is risk of child having children with cleft if their parent and sibling had clefts?
17%
What results from the failure of fusion of the medial nasal process with the maxillary process?
Cleft lip
When does the medial nasal process fuse with the maxillary process during gestation?
6 weeks
What results from the failure of the palatine shelves to fuse with each other, with the nasal septum or with the primary palate?
Cleft palate
When does fusion on the palatine shelves with each other, with the nasal septum and with the primary palate occur during gestation?
7-10 wks
What is the most common presentation of Clefting: cleft lip, cleft palate, or combined cleft lip and palate?
Combined cleft lip and palate
After CLP, which is the next most common cleft?
Isolated cleft palate (30%)
Which cleft is more associated with syndromes: combined cleft lip and palate or isolated cleft palate?
isolated cleft palate (has 50% association with syndrome)
What is the total number of syndromes that have associated cleft lip and palate presentation?
64
What are the 4 most common syndromes associated with CLP?
- Pierre Robin Syndrome
- Sticklet Syndrome
- Van der Woude syndrome
- Velofacial Syndrome (DiGeorge Syndrome)
What syndrome is not hereditary, has no gene defects, and presents with mandibular micrognathia, glossoptosis, and cleft palate?
Pierre Robin syndrome
What syndrome presents with cleft palate, small jaw, flat face, cataracts, blindness, and can be easy to miss?
Stickler syndrome
What syndrome characterized by pits of Lower Lip and Cleft lip/and or cleft palate. Due to Chromosome 1 gene mutation?
Van der Woude syndrome
What syndrome is characterized by cleft palate, heart defects, abnormal facial features, abnormal thymus and underactive parathyroid gland?
Velocardiaofacial syndrome (DiGeorge Syndrome)
What is the main concern at birth for baby with CLP?
The baby is unable to suckle and therefore will fail to thrive
How soon does the craniofacial team meet after the birth of a baby with CLP?
5 weeks after birth
How often does the craniofacial team visit the patient with CLP to check progress and make recommendations?
Approximately once a year
How old is a baby with CLP when the primary lip repair is done?
10 weeks
How old is a baby with CLP when cleft palate repair is done?
10-18
When is an alveolar bone graft done for a pt with CLP and why?
At 9-11 yrs old
Before maxillary canine eruption to prevent canine erupting into cleft
What is the rule of 10s for primary cleft lip surgery?
10 weeks
10 lbs
At least 10 hemoglobin count
Is primary cleft lip surgery the final cleft lip surgery?
No, passive surgery so growth not compromised due to scarring. Final lip repair completed once growth completed
Which muscle is affected in Cleft palate?
Medial levator palatine muscle
What is the goal of cleft palate repair?
To close the oronasal communication from the incisive foramen to uvula
To create dynamic soft palate musculature to aide normal speech
What is done to narrow the area air passes between oral and nasal cavity by joining parts of the soft palate with the posterior pharyngeal wall. Goal is to reduce the hypernasal voice during production of pressure sounds?
Pharyngeal Flap
Why is there only a 75% success rate for pharyngeal flap surgery?
Patients have already learned to speak a certain way
Is an alveolar bone graft done prior to or after expansion(Phase I orthodontics)?
Graft after expansion
What is the healing time for alveolar bone graft?
6 months
What percentage of CLP pts that will have a midfacial deficiency that can be corrected by orthognathic surgery?
20-30% of patients
What are the most common teeth affected in CLP?
Lateral incisors
Is bone grafting indicated prior to canine eruption?
Yes, it improves canine bony support
How often is the lateral incisor either missing or dysmorphic in CLP?
Two-thirds of the time
What can be done for missing lateral incisors in CLP?
Canine substitution
What is the phase I orthodontics for CLP?
Expansion prior to alveolar grafting
Patients with CLP are usually what Angle class and why?
Class III
Deficient maxilla growth
What is the phase II orthodontics option for CLP?
Definitive orthodontic treatment, possible orthognathic surgery
Why does a CLP palate need expansion?
It is V-shaped. Any V-shaped palate needs expansion.