Clearance Flashcards
1
Q
First order kinetics
A
Almost all drugs, clearance is constant over the concentration range, constant fraction of drug eliminated over time, elimination is not saturated, rate of elimination is proportional to the concentration
2
Q
Zero order kinetics
A
Constant amount of the drug is eliminated over time, clearance is saturated, independent of the amount of drug present
3
Q
Zero order kinetic drugs
A
Phenytoin, ethanol, aspirin (PEA)
4
Q
Clearance (CL)
A
Volume of blood cleared of drug per unit time
5
Q
Equation for clearance
A
Clearance = rate of elimination / drug concentration, clearance is in units of volume/time
6
Q
Elimination
A
Process of drug being cleared from the system, can occur in the kidney, lungs, liver, blood, etc, clearance predicts the rate of elimination
