Classification & Diagnosis

Question 1

What are the 4 criteria to diagnosis diabetes?

Answer 1

1. FBG _>126 mg/dL
2. 2-h PG _> 200 mg/dL
3. A1c _>6.5%
4. Class symptoms + rando glucose _>200mg/dL

Question 2

7 Conditions that alter A1c & glycemia

Answer 2

1. Sickle cell disease
2. 2nd & 3rd trimester
3. Postpartum
4. HIV
5. Hemodialysis
6. Recent blood loss or transfusion,
7. EPO therapy

Question 3

Name 3 Islet cell auto antibodies

Answer 3

1.Glutamic acid Decarboxylase (GAD)
2. Zinc transporter 8 (ZNT8)
3. Tyrosine phosphatase 2 (IA-2)

Question 4

Immune mediated diabetes accounts for how much of overall diabetes

Answer 4

5-10%

Question 5

Who should be screened for pre-DM or DM?

Answer 5

1. Overweight or Obesity & at least 1 risk factor (first-degree relative), high risk ethnicity, HTN, Dyslipidemia, etc

Question 6

What C-Peptide values are suggestive of T1DM & T2DM

Answer 6

> 600 pmol/L(non-fasting) is suggestive of T2DM and dc of insulin therapy . <200pmol/L is suggestive of T1DM

Question 7

What is monogenic diabetes? Name the 2 types

Answer 7

DM as a result of a single gene mutation. Neonatal & MODY

Question 8

During pregnancy, when should women be re-screened for GDM?

Answer 8

24 to 28 weeks

Question 9

How to screen for GDM?

Answer 9

75g OGTT. glucose measurements fasting, 1 hr & 2 hr. Dx when one value is met: Fasting _>92, 1 hr _>180 & 2 hr _>153